Psycho-Oncology
August 1, 2026
Hui Kou, Qiye Li, Xiaomei Hu et al.
Objectives: To examine whether a brief mindfulness training program was associated with changes in depressive symptoms among female patients with cancer, to explore potential psychological processes related to symptom change, and to examine differences in pre-to post-training changes according to baseline psychological risk profiles. Methods: This exploratory non-randomized controlled study...
Alpha psychiatry
August 2026
George Anderson
Understanding the physiological changes induced by ketamine in mood disorders, while reducing its side effects, is likely to contribute to a more comprehensive understanding of the physiology underlying mood disorders, as well as to the development of faster-acting and more efficacious antidepressant treatments. An extensive review of the literature on ketamine and the pathophysiology of...
Journal of Affective Disorders
August 1, 2026
João Paulo Atidio, Rodrigo Simonini Delfino, Igor Saque Garios et al.
Ketamine and esketamine have been increasingly used as adjunctive treatments for treatment-resistant depression (TRD), yet evidence on pharmacological interactions with commonly prescribed psychotropic medications remains limited. This study evaluated the association between concomitant lamotrigine, lithium, and benzodiazepine use and antidepressant outcomes during subcutaneous esketamine...
Pharmacology, Biochemistry, and Behavior
July 26, 2026
Peng Zhang, Mengyu Wu, Keke Zhang et al.
Esketamine has been approved for the treatment of treatment-resistant depression. However, there is an unmet clinical need to extend the duration of esketamine's action to reduce the high recurrence rate after drug withdrawal and the potential side effects of repeated esketamine use. Here, we found that increasing extracellular signal-regulated kinase (ERK) activity by pharmacologically...
Cell Reports
July 24, 2026
Viktor J Oláh, Isabelle F Witteveen, Tue G Banke et al.
GABAergic inhibitory interneurons balance brain activity by suppressing excessive excitatory signaling and shaping network oscillations. Despite this critical function, our understanding of how neural circuits regulate GABAergic systems remains limited. Although N-methyl-D-aspartate receptor (NMDAR) functionality is defined by the GluN2A-D subunits, the interneuron NMDAR subunit composition...
Psychology, Health & Medicine
July 19, 2026
Sheetal Rohit Sharma, Seeta Devi, Srikanth Pallerla et al.
Maternal mental health is a major global concern affecting both pregnant women and fetal development. Mindfulness-based interventions (MBIs) have shown benefits in improving maternal mental health. This study assessed the effects of digital and conventional face-to-face MBIs on psychological distress among pregnant women. Two independent reviewers conducted the literature search and study...
JMIR Research Protocols
July 17, 2026
Santosha Veeramachaneni, Elizabeth Park, Jeffrey Martin et al.
Hypnosis is a focused state of consciousness that enhances concentration, attention, and responsiveness to suggestion. It has shown efficacy in treating psychiatric disorders such as depression, anxiety, and posttraumatic stress disorder (PTSD). However, its potential for addressing burnout and related symptoms remains underexplored. This systematic review and meta-analysis aims to assess the...
Movement Disorders Clinical Practice
July 16, 2026
Kiran Kaur, W Alan Brown, Susanne Hoeppner et al.
Mindfulness-based approaches show promise for reducing tic severity, yet little is known about their effect on comorbid symptoms. The objective was to evaluate secondary outcomes from a pilot randomized controlled trial comparing mindfulness-based intervention for tics (MBIT) with psychoeducation, relaxation, and supportive therapy (PRST). Twenty-eight adults with Tourette's syndrome or...
JMIR Mental Health
July 15, 2026
Xichun Wu, Jackelyn De Alwis, Zenan Dou et al.
Background: Mobile mindfulness interventions have shown promise for reducing anxiety and depressive symptoms, but sustaining engagement remains a persistent challenge. Many digital programs still rely on formal practice that requires dedicated time, which may be difficult to integrate into daily life. Objective: This randomized controlled trial evaluated Habitual Mindfulness Practice (HMP), a...
Medycyna Paliatywna
July 15, 2026
Maciej Sulerzycki, Katarzyna Pomykała, Katarzyna Giemza et al.
In recent years, there has been a growing interest in the therapeutic use of psychedelics. In palliative medicine, they are being considered as an alternative approach to treating depression, existential distress, and chronic pain conditions. This review presents current literature on the use of psychedelic substances such as psilocybin, lysergic acid diethylamide,...