Journal of Affective Disorders
2023
Fan Zhang, Chengyu Wang, Xiaofeng Lan et al.
OBJECTIVE Hippocampal functional connectivity (FC) alterations, which may happen following ketamine treatment, play a key role in major depression remission. This study aims to investigate the resting-state FC changes of the hippocampus associated with clinical remission after repeated ketamine infusions. METHODS Forty-four major depressive patients received six intravenous ketamine (0.5 mg/kg)...
Advances in experimental medicine and biology
2023
Angelos Halaris, John Cook
The glutamatergic system is the primary excitatory pathway within the CNS and is responsible for cognition, memory, learning, emotion, and mood. Because of its significant importance in widespread nervous system function, it is tightly regulated through multiple mechanisms, such as glutamate recycling, microglial interactions, and inflammatory pathways. Imbalance within the glutamatergic system...
Journal of medical economics
2023
Maryia Zhdanava, Amanda Teeple, Dominic Pilon et al.
To describe real-world esketamine nasal spray access and use as well as healthcare resource use (HRU) and costs among adults with evidence of major depressive disorder (MDD) with suicidal ideation or behavior (MDSI). Adults with ≥1 claim for esketamine nasal spray and evidence of MDSI 12 months before/on the date of esketamine initiation (index date) were selected from Clarivate's Real World...
Revista da Associação Médica Brasileira
2023
Idevaldo Floriano, Antônio Silvinato, Wanderley Marques Bernardo
The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field to standardize how to conduct, and to assist in the reasoning and decision-making of doctors. The information provided by this project must be critically evaluated by the physician responsible for the conduct that will be adopted, depending on the conditions and the...
Complementary Medicine Research
2023
Wiebke Lehnert, Julia Günther-Pusch, Rainer Johannes Klement
Introduction: Anxiety, burnout, and depression cause a substantial psychological and social burden. Bioenergetic meditation (BM) was developed by Viktor Philippi as a method to strengthen psychological and physical health. This work presents the results of four feasibility studies investigating the effects of BM developed by Viktor Philippi as a support for people suffering from these...
International Journal of Nursing Studies
2023
Juan Li, Chang Li, Martine T E Puts et al.
BACKGROUND Lung cancer is one of the most common cancers and poses a physical and psychological threat to patients. Mindfulness-based interventions are emerging forms of psychotherapy that are effective in improving physical and psychological symptoms, but no review has summarized their effectiveness on anxiety, depression, and fatigue in people with lung cancer. OBJECTIVES To evaluate the...
Journal of Academic Research in Nursing
2023
Dilek Yıldırım, Özlem Akman
1 citation
The aim of this study is to assess the effect of mindfulness-based breathing-therapy on stress and well-being in individuals with chronic diseases. Methods: The study was conducted with single-blind randomised-controlled trial design and conducted with patients with chronic disease. 100 patients were randomly assigned to experimental (n=50) and control groups (n=50). Breathing-therapy received...
Journal of Clinical and Diagnostic Research
2023
Ajantha Antony, C Viji Prasad
Introduction: High levels of stress and anxiety are usually experienced by students as a result of peer pressure and concerns about college. Students who struggle to control their stress and anxiety may experience mood swings, behavioural changes, and even depression. Aim: To assess the effectiveness of mindfulness meditation on depression, anxiety, and stress among undergraduate nursing...
Mindfulness
2023
Barnaby D. Dunn, Hanna Wiedemann, Merle Kock et al.
Abstract Objectives Mindfulness-Based Cognitive Therapy for Depression (MBCT-D) has been shown to be effective at repairing positive affect deficits in depressed individuals, but the mechanism of action underpinning these changes has not been empirically examined. To address this issue, secondary analyses of two randomised controlled trials in individuals with residual depression were...
Progress in Brain Research
2023
Kenji Hashimoto
Neuroinflammation plays a key role in the pathogenesis of major depressive disorder (MDD), including treatment-resistant depression (TRD). Patients with TRD have higher levels of inflammatory biomarkers compared with responders to antidepressants. Multiple lines of evidence suggest that the gut-microbiota-brain axis via the vagus nerve plays a key role in neuroinflammation. Preclinical and...