Page 6 of 13: studies 101 to 120 of 247, newest first. Back to the depression overview
Depression and Anxiety July 22, 2021 E. Daly, Ibrahim Turkoz, Giacomo Salvadore et al.
Comorbid anxiety is generally associated with poorer response to antidepressant treatment. This post hoc analysis explored the efficacy of esketamine plus an antidepressant in patients with treatment‐resistant depression (TRD) with or without comorbid anxiety.
CNS Drugs July 20, 2021 Vera Miriam Ludwig, Cathrin Sauer, Allan H. Young et al. 23 citations
(Es)ketamine and monoamine oxidase inhibitors (MAOIs), e.g., tranylcypromine, are therapeutic options for treatment-resistant major depression. Simultaneous administration is currently not recommended because of concern about hypertensive crises. Our objective was to evaluate whether changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) during esketamine...
The Journal of Clinical Psychiatry July 16, 2021 Ibrahim Turkoz, Ella Daly, Jaskaran Singh et al. 21 citations
) and treatment-resistant depression (TRD) who did not meet response criteria within the first week of treatment. The current study is a pooled post hoc analysis of two phase 3, double-blind, active-controlled studies, conducted between August 2015 and February 2018, comparing ESK + AD with an oral antidepressant plus placebo (AD + PBO). Early treatment response was defined as a ≥ 50% decrease...
The Journal of Clinical Psychiatry July 13, 2021 Jolien K E Veraart, Sanne Y Smith-Apeldoorn, Jan Spijker et al. 31 citations
Objective: Ketamine shows rapid and robust antidepressant effects in clinical studies. Psychotic features are an exclusion criterion in most ketamine treatment studies based on the assumption that psychosis will increase with ketamine administration. As patients with treatment-resistant depression (TRD) often have psychotic features, and treatment-resistant depressive symptoms are also common...
Journal of Youth and Adolescence July 9, 2021 Estíbaliz Royuela-Colomer, Liria Fernández-González, Izaskun Orue
Mindfulness has been associated with fewer negative mental health symptoms during adolescence, but fewer studies have examined longitudinal associations between mindfulness and symptoms in conjunction with two vulnerability factors for psychopathology with mindfulness: rumination and impulsivity. This study examined longitudinal associations between internalizing symptoms (depression, anxiety,...
Iranian Journal of Public Health July 5, 2021 Hyunwoo Kang, Seyong Jang
Background: We aimed to conduct a mindfulness yoga program to treat the psychological problems of middle-aged men by examining the effects of a mindfulness yoga program on depression, self-esteem, and quality of life in this population. Methods: The participants included 50 middle-aged men (aged 40–60 yr) living in Seongnam-si, Korea. Twenty-five men were randomly assigned to the experimental...
July 5, 2021 Rosalind Watts 37 citations preprint
"The Psilocybin for Depression: The ACE Manual '' describes the structure, procedures, and scripts used in the two Imperial College London studies (Psilodep) researching psilocybin treatment for major depression.
BJS open July 1, 2021 Oliver Luton, O P James, K Mellor et al.
Introduction: Core surgical training programmes are associated with a high risk of burnout. This study aimed to assess the influence of a novel enhanced stress-resilience training (ESRT) course delivered at the start of core surgical training in a single UK statutory education body. Method: All newly appointed core surgical trainees (CSTs) were invited to participate in a 5-week ESRT course...
International Clinical Psychopharmacology July 1, 2021 Hikaru Hori
This article reports on the treatment of a patient with nightmares who was treated with doxazosin of an alpha 1-adrenergic antagonists. A 71-year-old Japanese major depressive disorder (MDD) woman experienced nightmares after the coronavirus disease 2019 pandemic. She had nightmares about being chased by a coronavirus and catching the corona virus. After adding doxazosin 1 mg daily in the...
Iranian Journal of Psychiatry July 2021 Masoume Sheikhzadeh, Zahra Zanjani, Alireza Baari
Objective: Cancer is associated with some psychological problems that play an important role in the severity and continuity of cancer. Cancer may lead to maladaptive psychological reactions such as anxiety, depression, and fatigue. Depression and anxiety are highly prevalent in cancer patients. This study aimed to compare the efficacy of mindfulness-based cognitive therapy (MBCT) and cognitive...
Neuroscience & Biobehavioral Reviews July 1, 2021 Stephen D Worrell, Thomas J Gould 47 citations
Excessive alcohol consumption is involved in 1/10 of deaths of U.S. working-age adults and costs the country around $250,000,000 yearly. While Alcohol Use Disorder (AUD) pathology is complex and involves multiple neurotransmitter systems, changes in synaptic plasticity, hippocampal neurogenesis, and neural connectivity have been implicated in the behavioral characteristics of AUD. Depressed...
Mustansiriya Medical Journal July 1, 2021 Raad Saady Madhloom
Major depressive disorder (MDD) is of influence on about 350 million individuals worldwide, which is causing disability consecution and damaging consequences to the affected community and individuals. Treatments as antidepressant are affecting the system of monoamine where symptoms of depressive were relived in about 50% of cases. Such ratio turns into obviously low in depressed persons who...
Journal of Psychiatric Research July 1, 2021 Ashley N. Siegel, Shakila Meshkat, Katie Benitah et al. 101 citations
Psychedelics are a hallucinogenic class of psychoactive drugs with the primary effect of activating non-ordinary states of consciousness. Due to the positive preliminary findings of these drugs in the treatment of psychiatric disorders, the number of registered clinical studies has risen significantly. In this paper, clinical studies registered on clinicaltrials.gov that evaluate the treatment...
The Journal of Alternative and Complementary Medicine June 29, 2021 Holger C Bringmann, Jill Vennemann, Julianne Gross et al.
Background: Meditation-Based Lifestyle Modification (MBLM) is a new mind–body intervention that is based on classical yoga; it implements virtue-based ethical living, physical yoga, and meditation in a therapeutic context. This qualitative study aimed at understanding better how depressive patients who received MBLM as a treatment experience intra- and interpersonal outcomes of their practice....
June 27, 2021 Annie M. Mccartney, Hugh McGovern, Alexander de Foe preprint
Psychedelic substances such as psilocybin and ketamine may represent the future of antidepressant treatment, due to their rapid and prolonged effects on mood and cognition. The current body of psychedelic research has focused on administration and treatment within a psychiatric context. Here, instead, we put to the test the contention that it is necessary to evaluate the current state of this...
Journal of Psychopharmacology June 26, 2021 Emma I Kopra, Valeria Mondelli, Carmine M. Pariante et al. 89 citations
Background: Ketamine is a novel rapid-acting antidepressant with high efficacy in treatment-resistant patients. Its exact therapeutic mechanisms of action are unclear; however, in recent years its anti-inflammatory properties and subsequent downstream effects on tryptophan (TRP) metabolism have sparked research interest. Aim: This systematic review examined the effect of ketamine on...
Pharmacy June 25, 2021 Linda Xing Yu Liu, Marina Golts, Virginia Fernandes 2 citations
The impact of depression is well described in the literature, and it is most prominent in patients who have trialed multiple treatments. Treatment-resistant depression (TRD) is particularly debilitating, and it is associated with significant morbidity and mortality. Despite this, there seems to be therapeutic inertia in adopting novel therapies in current practice. Ketamine is an...
The International Journal of Neuropsychopharmacology June 25, 2021 Jolien K E Veraart, Sanne Y Smith-Apeldoorn, I. M. Bakker et al. 44 citations
Abstract Background The use of ketamine for depression has increased rapidly in the past decades. Ketamine is often prescribed as an add-on to other drugs used in psychiatric patients, but clear information on drug-drug interactions is lacking. With this review, we aim to provide an overview of the pharmacodynamic interactions between ketamine and mood stabilizers, benzodiazepines, monoamine...
Korean journal of women health nursing June 24, 2021 Sun-Mi Kim, Sukhee Ahn
Purpose: The purpose of this study was to develop a self-transcendence enhancement program and examine its effect on self-transcendence, spiritual well-being, and psychological well-being in elderly women who live alone. Methods: A self-transcendence enhancement program was developed through theory, literature review, and in-depth interviews. The theoretical framework came from the...
OBM Neurobiology June 24, 2021 Sarah-Catherine Rodan, Phillip Aouad, Iain S. Mcgregor et al. 10 citations
Anorexia Nervosa (AN) is a major health problem with one of the highest mortalities and treatment costs of any psychiatric condition. Cognitive behavioural therapy (CBT) is currently the most widely used treatment for AN in adults but provides remission rates ≤ 50%. Treatment drop-out is exceedingly high and those that persevere with treatment often relapse, causing increased risk of morbidity...