Revista brasileira de neurologia
October 1, 2026
Fabricio Hampshire, Marleide da Mota Gomes, Christian Naurath et al.
Background: Neurospirituality is an emerging interdisciplinary framework integrating neuroscience, neurology, palliative care, and the medical humanities to address the spiritual and existential dimensions of health. Spirituality refers to meaning-making through connectedness beyond the self, whereas religiosity denotes organized beliefs, rituals, and communities. Objective: To review the...
Frontiers in Psychiatry
October 1, 2026
Matthew M. Kinney, Zackary L. Bowers
Ketamine has progressed from solely being an anesthetic agent to a drug of rising clinical and research interest due to its distinctive pharmacological properties. Its dissociative properties and rapid-acting antidepressant effects have made it a prominent area of investigation across many medical and psychiatric applications. This systematic review examines ketamine’s history, mechanisms of...
September 30, 2026
Abraham Peled
preprint
AbstractPsychiatry is the only branch of medicine that still diagnoses without reference to the organ it treats. Psychiatry: The Case for Starting Over argues that this is a structural failure rather than a temporary gap. The descriptive nosology inherited from Kraepelin and formalized in the DSM achieved diagnostic reliability at the cost of validity. Its categories were assembled by committee...
Preprints.org
September 29, 2026
Mouhammad Ousmane Ndiaye
preprint
A substantial proportion of patients with posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) do not respond to first-line treatment. Approximately 40% of PTSD patients do not respond to first-line psychotherapy, and 30.9% of MDD patients meet criteria for treatment-resistant depression. Yet standard polysomnography in these patients frequently shows REM sleep that appears...
Academia Neuroscience and Brain Research
September 28, 2026
Rob Dielenberg
Darwinian continuity and physical monism are traditionally thought to preclude free will, a conclusion reinforced by framing freedom as an instantaneous capacity to choose otherwise (the “branching problem”). This paper proposes an alternative: limited free will is the cumulative capacity of a physical system to modify the dispositions—the “bias function”—from which its future behavior emerges....
bioRxiv (Cold Spring Harbor Laboratory)
September 28, 2026
Gabriela Sawicka, Marian Martínez-Marín, Christopher Timmermann et al.
preprint
Psychedelic compounds such as N,N-dimethyltryptamine (DMT) induce rapid and profound changes in conscious experience, requiring neuroimaging measures that capture how brain dynamics evolve across space and time. Emerging evidence suggests that rotational (vortex-like) dynamics may contribute to the coordination of large-scale neural activity. Here, we introduce two vorticity-based metrics;...
September 25, 2026
Apoorav Sharma, Lovleen Marwaha
The neuroplasticity, the natural ability of the brain to change its structure and its functioning based on experience has become a unifying concept of neuroscience, psychology and even clinical practise. This chapter discusses the potential of neuroplasticity in achieving psychological wellbeing through deliberate cognitive and behavioral activities, including mindfulness, positive thinking,...
IntechOpen eBooks
September 24, 2026
Emel Uysal
Obsessive-compulsive disorder (OCD) is increasingly understood not simply as a disorder of intrusive thoughts, but as one of how those thoughts are interpreted, regulated, and invested with meaning. This narrative, conceptually oriented review, brings together three literatures that are usually treated separately – mindfulness, Wells’ metacognitive model, and the neurocognitive and neuroimaging...
Cureus
September 24, 2026
Angelos Kandilas, Alexandros Samolis, Theodosis Kalamatianos et al.
Self-awareness encompasses the capacity to recognize and evaluate information about oneself, including mental states, actions, autobiographical history, and bodily experience.Although closely related to consciousness, autobiographical memory, metacognition, clinical insight, anosognosia, and bodily selfconsciousness, these constructs are not interchangeable.This focused narrative review...
IGI Global eBooks
September 22, 2026
Srishti Muralidharan, Navya Charan
Anguish represents a profound form of human suffering that extends beyond ordinary emotional distress and engages interconnected neurobiological, cognitive and physiological systems. This chapter conceptualizes anguish as an active, embodied state characterised by persistent emotional arousal, self-referential processing, autonomic dysregulation, and meaning-making efforts. Drawing on...