Human Brain Mapping
2025
Isaac N Treves, Aaron Kucyi, Madelynn Park et al.
8 citations
Trait mindfulness refers to one's disposition or tendency to pay attention to their experiences in the present moment, in a non-judgmental and accepting way. Trait mindfulness has been robustly associated with positive mental health outcomes, but its neural underpinnings are poorly understood. Prior resting-state fMRI studies have associated trait mindfulness with within- and between-network...
Network Neuroscience
2025
Isaac N Treves, Winson F.z. Yang, Terje Sparby et al.
6 citations
Advanced meditation consists of states and stages of practice that unfold with mastery and time. Dynamic functional connectivity (DFC) analysis of fMRI could identify brain states underlying advanced meditation. We conducted an intensive DFC case study of a meditator who completed 27 runs of jhāna advanced absorptive concentration meditation (ACAM-J), concurrently with 7-T fMRI and...
Frontiers in Psychology
2025
Egbert Haverkamp, Erik Olsman, Branislava Ćurčić-blake et al.
1 citation
It has become increasingly accepted within psychotherapy to incorporate various forms of spirituality and religiosity to address the rising prevalence of mental health issues. This is well-founded, as a growing number of findings report benefits of spiritual practices for individuals experiencing depression, anxiety, and stress. However, science-based guidelines on how to embed spiritual...
International Review of Psychiatry
2025
Marjorie Woollacott, Marina Weiler
3 citations
In this review, we examine studies suggesting that conscious or mental awareness is constrained by our neural filters. These filters include sensory receptors, the ascending reticular activating system and the thalamus, the default mode network, and left hemisphere language centers. These filters limit our perception of the world to a narrow range of energy frequencies, make sense of space and...
Neuropsychiatric Disease and Treatment
2025
Daniel A Kinderlehrer
13 citations
The incidence of mental health disorders is increasing worldwide. While there are multiple factors contributing to this problem, neuroinflammation underlies a significant subset of psychiatric conditions, particularly major depressive and anxiety disorders. Anti-inflammatory interventions have demonstrated benefit in these conditions. Psilocin, the active ingredient of mushrooms in the...
International Journal of Molecular Sciences
December 20, 2024
Zuzanna Antos, Xawery Żukow, Laura Bursztynowicz et al.
14 citations
The rising prevalence of depression, with its associated suicide risk, demands effective fast-acting treatments. Ketamine has emerged as promising, demonstrating rapid antidepressant effects. While early studies show swift mood improvements, its precise mechanisms remain unclear. This article aims to compile and synthesize the literature on ketamine's molecular actions. Ketamine primarily works...
bioRxiv
December 17, 2024
Dian Lyu, Ram Adapa, Robin Carhart-Harris et al.
preprint
Abstract The relationship between the default mode network (DMN) and task-positive networks, such as the frontoparietal control network (FPCN), is a prominent feature of functional connectivity (FC) in the human brain. This relationship is primarily anticorrelated at rest in healthy brains and is disrupted in altered states of consciousness. Although the DMN and FPCN seem to perform distinct...
Neuroimage
December 14, 2024
Avijit Chowdhury, Marta Bianciardi, Eric Chapdelaine et al.
14 citations
Using a combination of fMRI, EEG, and phenomenology ratings, we examined the neurophenomenology of advanced concentrative absorption meditation, namely jhanas (ACAM-J), in a practitioner with over 23,000 h of meditation practice. Our study shows that ACAM-J states induce reliable changes in conscious experience and that these experiences are related to neural activity. Using resting-state fMRI...
Neuroscience Research
December 7, 2024
Atsushi Yamaguchi, Tatsuya Jitsuishi
The precuneus is an association area in the posteromedial cortex (PMC) that is involved in high-order cognitive functions through integrating multi-modal information. Previous studies have shown that the precuneus is functionally heterogeneous and subdivided into several subfields organized by the anterior-posterior and ventral-dorsal axes. Further, the precuneus forms the structural core of...
Molecular Psychiatry
December 1, 2024
Matteo Martino, Paola Magioncalda
13 citations
According to classical phenomenology, phenomenal experience is composed of perceptions (related to environmental stimuli) and imagery/ideas (unrelated to environmental stimuli). Intensity/vividness is supposed to represent the key phenomenal difference between perceptions and ideas, higher in perceptions than ideas, and thus the core subjective criterion to distinguish reality from imagination....