Phencyclidine (1-[1-phenylcyclohexyl]piperidine, PCP, hog, sheets, angel dust, Sernylan, and many other common names) is a primate anesthetic that has emerged as a common drug of abuse and as a medical emergency problem during the past few years. Phencyclidine abuse is primarily a youthful activity. It is associated with multiple clinical states, an unusual amount of aggressive behavior, and a...
Editorials1 March 1979The Paradox of Phencyclidine (PCP) AbuseRICHARD STILLMAN, M.D., ROBERT C. PETERSEN, PH.D.RICHARD STILLMAN, M.D.Search for more papers by this author, ROBERT C. PETERSEN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-428 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack...
The effects of lysergic acid diethylamide (LSD), d-amphetamine (AMP), chlorpromazine (CPZ), and the most active isomer of marihuana (delta9 - THC) on timing behavior were analyzed with a two-choice, discrete trial procedure in which pigeons were trained to discriminate visual stimuli that differed with respect to duration ('long' vs. 'short'). LSD (0.01, 0.04, 0.16 mg/kg) decreased response...
Consistent with predictions from Mosher's (1966) guilt construct, the present study found that high guilt males, compared with low guilt Ss, reported significantly less use of marijuana, depressant, stimulant and hallucinogenic drugs. Among all Ss who reported at least one use within each drug category, high guilt Ss rated their experiences as less pleasant and reported a higher frequency of...
Sixty experienced marihuana smokers participated in a study designed to assess the effect of a negative expectancy on marihuana intoxication. Two different environments, threat of shock and no-threat, were used under the drug conditions of marihuana and placebo. Ss came into the laboratory and adjusted a level of shock received at their fingertips, to a point of mild discomfort. Only those Ss...
Information processing was tested in 12 male subjects after smoking marihuana containing 0, 10, or 20 mg. of delta-9-tetrahydrocannabinol (THC) in three consecutive experimental sessions according to a Latin square protocol. Successful dose control was indicated both by the dose-related linear increase observed in heart rate and by preliminary assays of THC metabolites excreted in the urine....
In a controlled study on 38 volunteers the effects of 250 micrograms/kg N,N-dimethyltryptamine (DMT) i.m. on objective and performance tests measuring psychoticism according to Eysenck were assessed. The hypothesis was tested that subjects treated with DMT (N = 26) differ from those receiving placebo (N = 12) in the same way as endogenous psychotics differ from normals. Confirmation was...
During the period 1971–1973, it was found that 53 out of 91 young drug abusers in a psychiatric hospital had experienced flashbacks. This applied to as many as 50 out of the 65 patients who had used LSD, but also to abusers of organic solvents and cannabis. As many as 38% of the patients were found to be severely incapacitated by their flashbacks. On a personal follow-up 1 1/2–4 years after the...
9 Ss were requested to perceive simultaneously the taste of beer and a rhythmic sound, the pitch of which could be varied. The frequencies at which Ss experienced harmony between the taste and the sound were determined. At the pitch of harmony Ss reported characteristic experiences, e.g., optimum taste of the beer, rhythmic sensations in the head, and tickling sensations in the jaws and the...
Herbal preparations, designed to be smoked or ingested for "health and happiness", are promoted as legal hallucinogens, euphoriants, and marihuana substitutes. A total of 25 psychoactive substances have been identified in these products, and a number of intoxications have resulted from their short- or long-term use. Physicians should be alerted to the nature of these effects when taking drug...