Addiction Biology
June 2008
Fabrício A. Moreira, Beat Lutz
The identification of the cannabinoid receptor type 1 (CB1 receptor) was the milestone discovery in the elucidation of the behavioural and emotional responses induced by the Cannabis sativa constituent Delta(9)-tetrahydrocannabinol. The subsequent years have established the existence of the endocannabinoid system. The early view relating this system to emotional responses is reflected by the...
Molecular and cellular endocrinology
April 16, 2008
Ken Mackie
Because of the prominent psychoactive effects of cannabis and its preparations, much research has focused on the actions of cannabinoids, the primary psychoactive components of cannabis, on neuronal function. A convergence of research has identified (1) cannabinoid receptors, (2) endogenous compounds that activate these receptors (endocannabinoids), and (3) drugs that interact with these...
Journal of Neuroscience
March 5, 2008
K. Phan, Mike Angstadt, J. Golden et al.
The cannabinoid (CB) system is a key neurochemical mediator of anxiety and fear learning in both animals and humans. The anxiolytic effects of Δ9-tetrahydrocannabinol (THC), the primary psychoactive ingredient in cannabis, are believed to be mediated through direct and selective agonism of CB1 receptors localized within the basolateral amygdala, a critical brain region for threat perception....
Brazilian Journal of Psychiatry
March 1, 2008
Priscila Previato Almeida, Maria Alice Fontes Pinto Novaes, Rodrigo A. Bressan et al.
24 citations
OBJECTIVE: Cannabis is the most used illicit drug worldwide, however only a few studies have examined cognitive deficits related to its use. Clinical manifestations associated with those deficits include a motivational syndrome, impairment in cognitive flexibility, inattention, deficits in abstract reasoning and concept formation, aspects intimately related to the executive functions, which...
Neuroscience Letters
January 24, 2008
M E Page, V C Oropeza, E J Van Bockstaele
Delta(9)-tetrahydrocannabinol, the main psychoactive ingredient in marijuana, activates specific cannabinoid (CB) receptors to exert complex actions on modulatory neurotransmitters involved in attention and cognition. Previous research has demonstrated that systemic administration of the synthetic cannabinoid agonist, WIN 55,212-2, increases norepinephrine efflux in the frontal cortex. The...
Neuropharmacology
January 2008
Tiziana Rubino, Cinzia Guidali, Daniela Viganò et al.
There is a general consensus that the effects of cannabinoid agonists on anxiety seem to be biphasic, with low doses being anxiolytic and high doses ineffective or possibly anxiogenic. Besides the behavioural effects of cannabinoids on anxiety, very few papers have dealt with the neuroanatomical sites of these effects. We investigated the effect on rat anxiety behavior of local administration...
Neurochemistry International
January 2008
Zsuzsanna Sidló, Patricia H. Reggio, Margaret E Rice
The main psychoactive component of marijuana, Delta9-tetrahydrocannabinol (THC), acts in the CNS via type 1 cannabinoid receptors (CB1Rs). The behavioral consequences of THC or synthetic CB1R agonists include suppression of motor activity. One explanation for movement suppression might be inhibition of striatal dopamine (DA) release by CB1Rs, which are densely localized in motor striatum;...
Journal of ethnicity in substance abuse
2008
Kit Sang Leung, Jih-Heng Li, Wen-Ing Tsay et al.
Research among Asian users of methylenedioxy methamphetamine (MDMA), also known as Ecstasy, is rare. To evaluate the feasibility of a study on the abuse of and dependence on Ecstasy, two focus groups of users (n= 12) and health professionals (n=7) were conducted in Taiwan. Major results included blatant human testing with "candy and dinosaur girls" and a specific sequence of drugs called a...
Journal of Addictive Diseases
2008
Z Helen Wu, Jacques G Baillargeon, Abbey B Berenson et al.
This study examined the association of ecstasy (methylenedioxy-methylamphethamine) use with psychopathology among young, low-income females who sought care at university family planning clinics in Texas between December 2001 and May 2003. Participants reported drug use history and eight problem behavior syndromes by using the Young Adult Self-Report. The prevalence of ecstasy use was...
Journal for the Study of Radicalism
2008
Ann Larabee, Mathew J. Bartkowiak
5 citations
Interview with John Sinclair Ann Larabee and Mathew Bartkowiak In 1967, John Sinclair's TransLove Energies sponsored the Belle Isle "Love-in," a gathering of hippies that turned into a violent clash among the participants, biker gang members, and the Detroit police. Nearly 40 years later, on a peaceful, sunny afternoon, we sat down with John Sinclair on Belle Isle to discuss the state of...