American Journal of Psychiatry
June 1, 1976
Marc Galanter
The author describes a model of intoxicant use based on altered states of consciousness and reviews his own and others' research on marijuana to illustrate the utility of this model, which is derived from both introspective reports and observed data. The relationship of social behavior and cognitive functioning to the "intoxication state of consciousness" is discussed. This state of...
Science
May 21, 1976
Ronald I. Schoenfeld
118 citations
At a dose as low as 1 microgram per kilogram of body weight, lysergic acid diethylamide (LSD) significantly decreased the suppressive effect of electric shock on licking behavior of the rat. Attenuation of punishment was also obtained with mescaline, but neither dimethyltryptamine nor Δ 9 -tetrahydrocannabinol was active in this test. Cyproheptadine and α-propyldopacetamide, drugs that...
The American Journal of Drug and Alcohol Abuse
1976
C A Olmsted
The understanding of the effects of cannabinoids in human subjects has been obscured by a lack of knowledge about how the various active principles from marijuana act at the cellular level in the brain. For this reason the present study was undertaken to determine the effects of cannabinoids on the enzymes associated with the synaptic membranes. Electron micrographic analysis was performed to...
JAMA
October 20, 1975
A. D. Bloom
1 citation
Given the controversy of the late 1960s and early 1970s over the possible induction of chromosomal damage by psycho-active agents like LSD and marihuana, the peyote study of Teplitz et al (p 299), is reassuring. It is, first of all, comforting to know that in vivo studies of agents that are possible chromosomal mutagens can produce, when properly designed and executed, clear-cut results....
International Journal of the Addictions
1975
G G Nahas, P Zeidenberg, C Lefebure
Chronic cannabis intoxication of a significant fraction of the male population still prevails in Morocco. The preparation used (kif) is a powder made from the dried flower of the female plant. It contains 2 to 3% THC and is smoked mixed with tobacco (1/3 of the mixture). Cultivation of kif is tolerated in an area of 60 square miles in the high Rif mountain of Northern Morocco, where it...
JAMA
November 11, 1974
Miles K. Crowder
16 citations
To the Editor.— In a recent issue (229:763, 1974), Shaffer describes a series of cases characterized by anesthesia, analgesia, nystagmus, dizziness, diplopia, visual distortions, and psychosis. These findings were attributed to ketamine, a derivative of phencyclidine. Phencyclidine is a major component of street drug preparations.1In one series, phencyclidine was detected in 184 of 237 street...
British Journal of Pharmacology
February 1974
E A Carlini, I G Karniol, P F Renault et al.
1 The pharmacological potencies of the resins from three different samples of Brazilian marihuana (A, B and C) were determined through corneal areflexia in rabbits, decrease of spontaneous motor activity and induction of catatonia in mice, and decrease of rope climbing performance of rats.2 The Delta(9)-tetrahydrocannabinol (Delta(9) THC) content of the marihuanas, measured by gas...
International Journal of Clinical and Experimental Hypnosis
1972
David Whitman van Nuys
4 citations
Abstract 47 undergraduate male volunteers were asked 2 questions relating to their use of marijuana and/or psychedelic drugs (e.g., LSD, mescaline, psilocybin) and were administered the Harvard Group Scale of Hypnotic Susceptibility, Form A (HGSHS:A). The HGSHS:A scores of Ss who had, at some time, taken any of these drugs averaged 2 points higher than scores of Ss who had not. Further research...
Bulletin of the School of Oriental and African Studies
June 1, 1971
John Brough
25 citations
The importance of the Soma-plant in Vedic religion has never been underestimated. Among the rituals of the Yajurvedic texts, the soma -sacrifices are among the most elaborate and important, and are described in minute detail in the Brāhmaṇas and Śrauta-sūtras . These later texts nevertheless continue a direct tradition from the Ṛgveda , which can be seen to reflect an earlier stage in the...
Science
August 7, 1970
Raphael Mechoulam, A Shani, H Edery et al.
A sample of hashish was extracted consecutively with petroleum ether, benzene, and methanol. When tested intravenously in monkeys only the petroleum-ether fraction was active. This material was further fractionated. The only active compound isolated was Delta(1)-tetrahydrocannabinol. Cannabinol, cannabidiol, cannabichromene, cannabigerol, and cannabicyclol when administered together with...