Journal of Cannabis Research
May 31, 2025
Michael Von Gunten, Seth Hoffman, Addison Smartt et al.
Ventral tegmental area (VTA) dopamine signaling plays a key role in reward learning and drug dependence. VTA dopamine cell activity is regulated in part by local GABA interneurons, which participate in regulating reward prediction. Previously, our lab identified a cannabinoid type 1 receptor (CB1)-dependent form of excitatory long-term depression (LTD) in VTA GABA cells. LTD was eliminated in...
Journal of Cannabis Research
May 23, 2025
Margy Y. Chen, Ashley Brooks-Russell, Angela D Bryan et al.
As cannabis products become increasingly accessible and novel modes of administration like dabbing and vaping gain popularity, understanding how these modes impact use experiences and abuse liability is crucial. Existing studies primarily utilized laboratory settings with lower-potency research-grade cannabis, failing to capture common modes among individuals who use higher-potency legal market...
Drug Testing and Analysis
May 21, 2025
Donata Favretto, Antonello Cirnelli, Roberto Pertile et al.
2 citations
A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness. Intubation was needed for the onset of dyspnea, so fentanyl and ketamine were administered during the...
Neuropsychopharmacology
May 2025
Janna Cousijn, Yara J Toenders, Anne Marije Kaag et al.
While Cannabis use disorder (CUD) is twice as prevalent in males, females transition more quickly from heavy use to CUD and experience more severe withdrawal. These clinically relevant sex differences contrast the lack of knowledge about the underlying brain mechanisms. This study investigated the relationship between CUD and resting-state functional brain connectivity (RSFC), assessing...
Drug and Alcohol Dependence
May 1, 2025
Spruha Joshi, Kyle M. Snyder, Christian Thurstone et al.
An increasing number of U.S. states have legalized cannabis, but the effect on adolescent and young adult psychosis-related hospitalizations remains under-studied. Using data from Denver Health between 2005–2020, we examined associations between implementation of the Ogden Memo (expanding use of medical cannabis in Colorado, October 2009) and Amendment 64 (legalizing adult-use cannabis in...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
May 1, 2025
Danial Behzad, S. Patel, R. Besa et al.
Novel methods of cannabis use are becoming popular, but the differential impact of these new methods on cognition have not been widely studied. Further, the impact of cannabis on cognition is mediated by delta-9-tetrahydrocannabinol (THC), but few studies have directly compared the pharmacokinetics of different methods. This systematic review (PROSPERO, CRD42023442731) was conducted to...
Neurotoxicology
May 1, 2025
Giulia Tomagra, Nikita Gandlevskiy, Elena Rosso et al.
3 citations
Cannabis sativa L. presents a very complex composition that includes several secondary metabolites besides the two main compounds, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Many of these minor cannabinoids are still under investigation and are arousing increasing interest for their biological effects and potential therapeutic roles. Cannabis sativa extracts, either properly purified...
Neuropsychopharmacology
May 1, 2025
Francisco Madrid-Gambin, Noemí Haro, Natasha L. Mason et al.
4 citations
Acute intoxication from Δ9-tetrahydrocannabinol (THC, the primary active ingredient of cannabis) can lead to neurocognitive impairment and interference with day-to-day operations, such as driving. Present evaluations of THC-induced impairment in legal settings rely on biological drug tests that solely establish cannabis use, rather than cannabis impairment. The current study evaluated the...
Neuroscience & Biobehavioral Reviews
May 1, 2025
C Schiemer, Mathew J Summers, Kayla B Stefanidis
2 citations
Electroencephalography (EEG) has potential to provide a sensitive measure of the acute neurophysiological response to cannabis administration. As delta-9-tetrahydrocannabinol (THC; the psychoactive constituent of cannabis) can induce transient neurocognitive impairments that differ as a function of tolerance and dose, understanding the neural profile related to intoxication would be of great...
npj Mental Health Research
April 24, 2025
Jacob Ross, Bruna Cuccurazzu, Dylan Delmar et al.
1 citation
Posttraumatic stress disorder (PTSD) is associated with poor hippocampal function and disrupted pattern recognition. Cannabis use is highly prevalent in individuals with PTSD, yet the impact on these cognitive functions is poorly understood. Participants (n = 111) with a range of PTSD symptoms with and without regular cannabis use completed the mnemonic similarity task. We hypothesized that...