Palgrave Macmillan UK eBooks
2015
Mathieu Perrot
1 citation
In 1954, at the age of 55, Henri Michaux was a well-published writer and a seasoned traveller. As a young man in the 1930s and 1940s, the Belgian poet and painter had voyaged across East Asia, Central and South America, which resulted in a large portion of his oeuvre: well-known accounts, both real and imaginary, of his trips abroad, fictional ethnographies, and numerous volumes of poetry....
Brain Injury
2015
Musa Sami, Katie Piggott, Claire Coysh et al.
11 citations
This study describes the case of a 57 year old gentleman with a previous severe brain injury who developed a severe psychotic disorder 19 years after the injury. This appears to have been precipitated by heavy psychedelic substance use, including cannabis, salvia divinorum, ketamine, LSD, cocaine and DMT amongst others. The psychosis remained in the absence of drug intoxication and was...
Journal of Psychoactive Drugs
2015
Joseph El-Khoury, Nayiri Sahakian
15 citations
The association of substance abuse and psychotic disorders is of interest to clinicians, academics, and lawmakers. Commonly abused substances, such as cannabis, cocaine, amphetamines, and alcohol, have all been associated with substance-induced psychosis. Hallucinogens can induce desired psychedelic effects and undesirable psychomimetic reactions. These are usually transient and resolve once...
European Journal of Neuroscience
December 2014
Neeraj Soni, Shankha Satpathy, Kristi A. Kohlmeier
Marijuana, which acts within the endocannabinoid (eCB) system as an agonist of the cannabinoid type 1 receptor (CB1R), exhibits addictive properties and has powerful actions on the state of arousal of an organism. The laterodorsal tegmental nucleus (LDT), as a component of the reticular activating system, is involved in cortical activation and is important in the development of drug...
Frontiers in Neuroscience
November 10, 2014
Justine Renard, Marie-Odile Krebs, Gwenaëlle Le Pen et al.
146 citations
Marijuana is the most widely used illicit drug among adolescents and young adults. Unique cognitive, emotional, and social changes occur during this critical period of development from childhood into adulthood. The adolescent brain is in a state of transition and differs from the adult brain with respect to both anatomy (e.g., neuronal connections and morphology) and neurochemistry (e.g.,...
Drug and Alcohol Dependence
November 1, 2014
Marisol S. Castaneto, David A. Gorelick, Nathalie A. Desrosiers et al.
Synthetic cannabinoids (SC) are a heterogeneous group of compounds developed to probe the endogenous cannabinoid system or as potential therapeutics. Clandestine laboratories subsequently utilized published data to develop SC variations marketed as abusable designer drugs. In the early 2000s, SC became popular as "legal highs" under brand names such as Spice and K2, in part due to their ability...
Journal of Psychopharmacology
November 1, 2014
Eduardo Ekman Schenberg, Maria Angélica de Castro Comis, Bruno Rasmussen Chaves et al.
110 citations
Ibogaine is an alkaloid purported to be an effective drug dependence treatment. However, its efficacy has been hard to evaluate, partly because it is illegal in some countries. In such places, treatments are conducted in underground settings where fatalities have occurred. In Brazil ibogaine is unregulated and a combined approach of psychotherapy and ibogaine is being practiced to treat...
The International Journal of Neuropsychopharmacology
October 31, 2014
David D. Aguilar, Li Chen, Daniel J Lodge
Schizophrenia is a debilitating disorder that affects 1% of the US population. While the exogenous administration of cannabinoids such as tetrahydrocannabinol is reported to exacerbate psychosis in schizophrenia patients, augmenting the levels of endogenous cannabinoids has gained attention as a possible alternative therapy to schizophrenia due to clinical and preclinical observations. Thus,...
Journal of Clinical Psychopharmacology
October 2014
Colin Cameron, Diane Watson, Jeffrey D. Robinson
Nabilone is a synthetic cannabinoid that has shown promise for the treatment of posttraumatic stress disorder (PTSD)-related insomnia and nightmares as well as efficacy in the management of chronic pain. It has also been proposed for harm reduction in cannabis dependence. Its effectiveness for management of concurrent disorders in seriously mentally ill correctional populations has not been...
Neurobiology of Learning and Memory
September 2014
Christine A Rabinak, Mike Angstadt, Maryssa Lyons et al.
Pre-extinction administration of Δ9-tetrahydrocannibinol (THC) facilitates recall of extinction in healthy humans, and evidence from animal studies suggest that this likely occurs via enhancement of the cannabinoid system within the ventromedial prefrontal cortex (vmPFC) and hippocampus (HIPP), brain structures critical to fear extinction. However, the effect of cannabinoids on the underlying...