Neurobiology of Learning and Memory
September 1, 2024
David S Jacobs, Alina P Bogachuk, Chloé L Le Moing et al.
4 citations
Psilocybin may provide a useful treatment for mood disorders including anxiety and depression but its mechanisms of action for these effects are not well understood. While recent preclinical work has begun to assess psilocybin's role in affective behaviors through innate anxiety or fear conditioning, there is scant evidence for its role in conflict between reward and punishment. The current...
Neurobiology of Learning and Memory
September 1, 2021
Claudia Picard-Deland, Tomy Aumont, Arnaud Samson-Richer et al.
Sleep facilitates memory consolidation through offline reactivations of memory traces. Dreaming may play a role in memory improvement and may reflect these memory reactivations. To experimentally address this question, we used targeted memory reactivation (TMR), i.e., application, during sleep, of a stimulus that was previously associated with learning, to assess whether it influences...
Neurobiology of Learning and Memory
May 25, 2021
Igor Magaraggia, Zilla Kuiperes, Rudy Schreiber
49 citations
The high symptomatic and biological heterogeneity of major depressive disorder (MDD) makes it very difficult to find broadly efficacious treatments that work against all symptoms. Concentrating on single core symptoms that are biologically well understood might consist of a more viable approach. The Research Domain Criteria (RDoC) framework is a trans-diagnostic dimensional approach that...
Neurobiology of Learning and Memory
December 5, 2019
Chunhui Wu, Yu Wang, Yang He et al.
Clinical and preclinical researches have shown that sub-anesthetic ketamine elicits sustained antidepressant effects for up to 1-2 weeks. Pharmacokinetics studies (t1/2 = 23 min) in mice showed no ketamine residue at 24 h after sub-anesthetic or anesthetic ketamine administration. Therefore, this study aims to reveal the mechanism underlying these different biological functions at 24 h after...
Neurobiology of Learning and Memory
December 2017
María Pilar García-pardo, Jose Enrique De la Rubia Ortí, Maria Asunción Aguilar Calpe
Drug addiction continues being a major public problem faced by modern societies with different social, health and legal consequences for the consumers. Consumption of psychostimulants, like cocaine or MDMA (known as ecstasy) are highly prevalent and cognitive and memory impairments have been related with the abuse of these drugs. The aim of this work was to review the most important data of the...
Neurobiology of Learning and Memory
July 1, 2015
Elaine Van Rijn, J-B Eichenlaub, Penelope A. Lewis et al.
Incorporation of details from waking life events into Rapid Eye Movement (REM) sleep dreams has been found to be highest on the night after, and then 5-7 nights after events (termed, respectively, the day-residue and dream-lag effects). In experiment 1, 44 participants kept a daily log for 10 days, reporting major daily activities (MDAs), personally significant events (PSEs), and major concerns...
Neurobiology of Learning and Memory
July 1, 2015
Tore Nielsen, C O'Reilly, Michelle Carr et al.
Memory consolidation is associated with sleep physiology but the contribution of specific sleep stages remains controversial. To clarify the contribution of REM sleep, participants were administered two REM sleep-sensitive tasks to determine if associated changes occurred only in REM sleep. Twenty-two participants (7 men) were administered the Corsi Block Tapping and Tower of Hanoi tasks prior...
Neurobiology of Learning and Memory
September 9, 2014
Tracey J. Shors, Ryan L Olson, Marsha E Bates et al.
New neurons are generated in the hippocampus each day and their survival is greatly enhanced through effortful learning (Shors, 2014). The numbers of cells produced can be increased by physical exercise (van Praag, Kempermann, & Gage, 1999). These findings inspired us to develop a clinical intervention for humans known as Mental and Physical Training, or MAP Training. Each session consists of...
Neurobiology of Learning and Memory
September 2014
Christine A Rabinak, Mike Angstadt, Maryssa Lyons et al.
Pre-extinction administration of Δ9-tetrahydrocannibinol (THC) facilitates recall of extinction in healthy humans, and evidence from animal studies suggest that this likely occurs via enhancement of the cannabinoid system within the ventromedial prefrontal cortex (vmPFC) and hippocampus (HIPP), brain structures critical to fear extinction. However, the effect of cannabinoids on the underlying...
Neurobiology of Learning and Memory
March 1, 2011
The effects of binge MDMA on acquisition and reversal learning in a radial-arm maze task.
Neurobiology of Learning and Memory
February 28, 2009
Erin J. Wamsley, John S. Antrobus
Research in animals has demonstrated that patterns of neural activity first seen during waking experience are later "replayed" during sleep, in hippocampal and cortical networks. The characteristics of memory reactivation during human sleep, however, have not yet been fully described. Meanwhile, the possible relationship of dreaming to this "replay" of memories in the sleeping brain is entirely...