Journal of Psychoactive Drugs
December 1, 2009
Katy A. Jones, Mark Blagrove, A. C. Parrott
41 citations
This study investigated the associations between chronic cannabis and Ecstasy/MDMA use and one objective and two subjective measure of creativity. Fifteen abstinent Ecstasy users, 15 abstinent cannabis users, and 15 nondrug-user controls, completed three measures of creativity: the Consequences behavioral test of creativity, self-assessed performance on the Consequences test, and Gough's Trait...
The British Journal of Psychiatry
November 30, 2009
Marta Di Forti, Craig Morgan, Paola Dazzan et al.
577 citations
BACKGROUND: People who use cannabis have an increased risk of psychosis, an effect attributed to the active ingredient Delta 9-tetrahydrocannabinol (Delta 9-THC). There has recently been concern over an increase in the concentration of Delta 9-THC in the cannabis available in many countries. AIMS: To investigate whether people with a first episode of psychosis were particularly likely to use...
Neuropsychopharmacology
November 18, 2009
Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology.
Schizophrenia Bulletin
November 13, 2009
Ana González-Pinto, Susana Alberich, Sara Barbeito et al.
Objective: To examine the influence of cannabis use on long-term outcome in patients with a first psychotic episode, comparing patients who have never used cannabis with (a) those who used cannabis before the first episode but stopped using it during follow-up and (b) those who used cannabis both before the first episode and during follow-up. Methods: Patients were studied following their first...
Drug and Alcohol Dependence
November 1, 2009
Staci A Gruber, Jadwiga Rogowska, Deborah A Yurgelun-Todd
More than 94 million Americans have tried marijuana, and it remains the most widely used illicit drug in the nation. Investigations of the cognitive effects of marijuana report alterations in brain function during tasks requiring executive control, including inhibition and decision-making. Endogenous cannabinoids regulate a variety of emotional responses, including anxiety, mood control, and...
British Journal of Pharmacology
November 2009
Nathan Gunasekaran, L E Long, B L Dawson et al.
Delta(9)-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, accumulates in adipose tissue where it is stored for long periods of time. Here we investigated whether conditions that promote lipolysis can liberate THC from adipocytes to yield increased blood levels of THC. In vitro studies involved freshly isolated rat adipocytes that were incubated with THC before exposure...
October 30, 2009
O. Oshodi, O. Ikeji, S. Olotu et al.
Hospital records of patients seen between 1999 and 2002 were carefully examined. A questionnaire was used to extract relevant information from the case records and clinical diagnosis was made using the ICD-10. Cases that had evidence of pre-existing psychiatric disorder, family history of mental illness or heavy use of alcohol and/or tobacco were excluded. Out of 6,556 patients that were seen...
Brain Stimulation
October 2009
Giacomo Koch, Francesco Mori, Claudia Codecà et al.
In animal models, the cannabinoid system has been convincingly implicated in the regulation of long-lasting synaptic plasticity. Both long-term potentiation (LTP) and depression (LTD) phenomena can be induced in the human motor cortex by transcranial magnetic theta burst stimulation (TBS). Here, we explored the potential involvement of the cannabinoid system in TBS-induced synaptic plasticity...
Psychological Medicine
October 2009
Paul D. Morrison, V Zois, D A McKeown et al.
Recent work suggests that heavy use of cannabis is associated with an increased risk of schizophrenia-like psychosis. However, there is a dearth of experimental studies of the effects of the constituents of cannabis, such as Delta9-tetrahydrocannabinol (THC). In a study of intravenous (i.v.) synthetic THC in healthy humans, we aimed to study the relationship of the psychotic symptoms induced by...
American Journal of Psychiatry
October 1, 2009
Michael T Compton, M. Kelley, Claire E. Ramsay et al.
Objective Several reports suggest that cannabis use is associated with an earlier age at onset of psychosis, though not all studies have operationalized cannabis use as occurring prior to onset of symptoms. This study addressed whether pre-onset cannabis use (and alcohol and tobacco use) is associated with an earlier age at onset of prodromal and psychotic symptoms. Additionally, effects of the...