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Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology.

Neuropsychopharmacology November 18, 2009 DOI: 10.1038/npp.2009.184 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Observational cohort Peer reviewed
Topics Cannabis CBD
Key findings THC and CBD have opposite effects on brain function and psychopathology: THC induces psychotic symptoms and alters brain activity, while CBD shows antipsychotic properties and modulates brain activity in opposing directions.

Abstract

Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology.

Comparable studies

Other observational and cohort studies on CBD, most cited first.

Study Year Design Participants
Telling true from false: cannabis users show increased susceptibility to false memories Chronic cannabis users 2015 Observational cohort
Psicosis inducida por cannabis: características clínicas y su diferenciación con la esquizofrenia con y sin consumo de cannabis asociado Inpatients with psychosis 2020 Observational cohort n = 307
Theta and Alpha Oscillatory Activity During Working Memory Maintenance in Long-Term Cannabis Users: The Importance of the Polydrug Use Context Regular cannabis users (exclusive and polydrug) and non-using controls 2021 Observational cohort n = 87
A brain imaging study of dopamine receptor D2 availability in cannabis dependent users after recovery from cannabis-induced psychosis Abstinent ex cannabis-dependent users treated for cannabis-induced psychosis, abstinent... 2023 Observational cohort n = 25
Determination of tetrahydrocannabinol and cannabidiol contents in Cannabis sativa L. samples in Togo using gas chromatography-mass spectrometry Cannabis sativa L. plant samples collected from various towns in Togo 2023 Observational laboratory analysis

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