Neuroscience & Biobehavioral Reviews
June 1, 2017
Kristine Rømer Thomsen, M. B. Callesen, S. W. F. Ewing
Cannabis use represents a major public health issue throughout the globe. Yet, we still lack the most fundamental knowledge on long-term effects of cannabis on neural, cognitive, and behavioral function. Part of this stems from how cannabis has been measured historically. To this end, most empirical examinations of cannabis have consolidated all types of cannabis collectively. However, this...
Psychoneuroendocrinology
May 30, 2017
E. Carol, R. L. Spencer, V. Mittal
Recent studies have posited a relationship between cannabis use and the biological stress system, but this critical relationship has not been evaluated during the ultra high-risk (UHR) period immediately preceding the onset of psychotic disorders. Salivary cortisol samples were collected on 46 UHR and 29 control adolescents; these individuals were assessed for current cannabis use with a urine...
Psychological Medicine
May 30, 2017
Chandni Hindocha, Tom P. Freeman, Joanna Xia et al.
104 citations
BACKGROUND: Cannabis and tobacco have contrasting cognitive effects. Smoking cannabis with tobacco is prevalent in many countries and although this may well influence cognitive and mental health outcomes, the possibility has rarely been investigated in human experimental psychopharmacological research. METHOD: The individual and interactive effects of cannabis and tobacco were evaluated in 24...
Behavioural Brain Research
May 1, 2017
Yasser A Khadrawy, Hussein G Sawie, Omar M E Abdel-Salam et al.
Cannabis sativa is one of the most widely recreational drugs and its use is more prevalent among depressed patients. Some studies reported that Cannabis has antidepressant effects while others showed increased depressive symptoms in Cannabis users. Therefore, the present study aims to investigate the effect of Cannabis extract on the depressive-like rats. Twenty four rats were divided into:...
Current Addiction Reports
April 29, 2017
Marco Colizzi, Sagnik Bhattacharyya
Purpose of ReviewThe lack of clarity about the effect of cannabis use on cognition may be attributable to the considerable heterogeneity among studies in terms of cannabis composition. This article selectively reviews studies examining the distinctive effects of cannabinoids on human cognition, particularly those of delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD).Recent...
Psychology of Addictive Behaviors
April 17, 2017
J. Scott, Daniel H. Wolf, Monica E. Calkins et al.
Cannabis use in youth is rising and has been linked to deficits in cognitive functioning. However, cognitive findings have primarily been based on small samples of users seeking treatment, and few studies have evaluated cognition in occasional cannabis users. Here, we examined 4,568 adolescents and young adults (ages 14–21 years) drawn from the Philadelphia Neurodevelopmental Cohort, a...
Neuropharmacology
April 14, 2017
Romina Mizrahi, Jeremy J. Watts, Kuei Yuan Tseng
Studies from preclinical animal models indicate that sustained activation of CB1 receptor signaling is a major contributing factor for the onset of cognitive deficits associated to chronic cannabis use, in particular within the working memory and decision-making domains. Yet, very few studies have been designed to directly assess the role of CB1 receptors in mediating the effects of cannabis on...
European Psychiatry
April 1, 2017
F. Dumitrescu
Introduction: “Bath salts” target the endocannabinoid system in a similar manner to cannabis. In the case of designer drug misuse, subjects seem to be at higher risk of psychotic symptoms. Aims: To investigate the nature and frequency of psychotic symptoms associated with cannabis and/or bath salts misuse in a male inpatient population. Method: The files of 107 patients admitted to the...
European Psychiatry
April 1, 2017
M. Gomez Revuelta, María Juncal Ruiz, O. Porta Olivares et al.
Introduction The association between cannabis and psychosis makes crucial the intervention on cannabis use disorder at first episodes of psychosis (FEP), especially among young population. In this group of patients, the harmful potential of cannabis is more evident by its influence on neurodevelopment. However, the nature of the association cannabis-psychosis is not clearly described. It seems...
European Psychiatry
April 1, 2017
A. Oda
BackgroundWith the rapid and intensive spread of marihuana abuse among youth, Japanese society is focusing on law enforcement against drug abusers. In 2016, a mass killing allegedly committed by a marihuana abuser was reported in Japan.ObjectivesTo consider that common recognition of the diverse process and potential risks of cannabis psychosis should be shared among psychiatrists.AimsElicit...