Whole plants and mushrooms have been used in systems of traditional medicine and health around the globe for millennia, and these more wholistic approaches are increasingly being embraced in modern Western societies. Cannabis and psilocybin are perhaps two of the most salient examples given current public and academic interests. Greater accessibility, along with expanding socioeconomic and...
Este artigo apresenta o protocolo experimental e a base teórica atualizada do Experimento do Século, cujo objetivo central é validar empiricamente a Arquitetura Holográfica da Construção da Realidade (AHCR 2.0), modelo que propõe a consciência como variável físico-informacional mensurável no processo de construção da realidade observável.A origem dessa abordagem remonta à publicação do primeiro...
Importance: Psychedelic drugs possess acute psychoactive effects that can compromise blinding integrity in randomized clinical trials (RCTs). Functional unblinding, when participants or raters correctly identify treatment allocation based on subjective effects, may bias outcomes through expectancy effects, challenging the validity of efficacy estimates and regulatory acceptance. Objective: To...
Interest in classical psychedelics as potential treatments for ADHD has grown alongside broader psychiatric psychedelic research, but ADHD-specific evidence remains limited. This systematic review examined prospective and experimental studies on whether classical psychedelics, including microdosing-like use and retreat-based exposure, are associated with changes in adult ADHD symptoms and...
Altered states of consciousness (ASC) represent a universal human capacity for accessing and transforming the subconscious mind, employed across cultures and millennia through diverse contemplative, somatic, pharmacological, ritual, and technological modalities. This comprehensive review synthesizes evidence from over 25 distinct disciplines spanning five clusters: (A) contemplative and...
Psychedelic drugs are re-emerging as promising scientific and clinical tools. However, despite a rapidly expanding literature on their therapeutic value, the neural mechanisms underlying psychedelic effects remain unclear. Resting-state functional magnetic resonance imaging studies of acute psychedelic effects, conducted independently by several research groups, have so far yielded fragmented...
Carl G. Jung (1875-1961) tratou de pacientes com problemas relacionados ao álcool e teve influência na fundação dos Alcoólicos Anônimos (AA). A despeito de ter tomado conhecimento sobre os psicodélicos, jamais os experimentou e desaprovava seu uso. No campo da psicologia analítica, há estudos sobre o tema das drogas, mas tal temática foi, por vezes, retratada apenas em sua faceta negativa. O...
Expanding regulation and increased use of psychedelic substances requires surveillance of behaviors and health outcomes in the United States. Widely comprehendible terminology is important for surveys. The objective of this study was to determine what psychedelic terminology is preferred among adults who used a psychedelic in the past 12 months. A cross-sectional survey measuring psychedelic...
This paper aims to identify the effects of ayahuasca on humans and more specifically how this substance defines changes within psychological and behavioral patterns, including experience of emotions, decision-making processes, and life changes. The demand for the new-wave of antidepressants based on psychedelic substances places emphasis on the study of how the powerful ayahuasca, a...
The global psychedelic field has been narrated through the metaphor of a “Psychedelic Renaissance.” While effective in mobilizing public interest, this framing reproduces Eurocentric histories, Darwinian narratives of sociocultural progress, and biomedical logics that marginalize Indigenous sciences and relational ecologies. Enduring coloniality and conflicts concerning biomedicalization,...