PsychedelicsMarch 1, 2026A.m Ortiz Bernal, C L Raison, A.m Vargas Prieto et al.
5-methoxy- N,N -dimethyltryptamine (5-MeO-DMT) is a potent, short-acting psychedelic compound found in several South American plant species and in the glandular secretions of Incilius alvarius, a toad native to the Sonoran Desert. While plant-based snuff preparations containing 5-MeO-DMT have documented use in Indigenous Caribbean and South American contexts, recent claims that toad-derived...
The legal status of psilocybin mushrooms in Brazil remains ambiguous, despite increasing global scientific and public interest in their therapeutic and ceremonial use. This commentary examines the regulatory uncertainty surrounding psilocybin mushrooms in Brazil and situates the debate within broader legal, drug policy, public health, and Indigenous rights discussions. Building on academic...
Novos DebatesFebruary 11, 2026Karoliny Felipe Martins
Em um contexto marcado pelo aumento do uso de drogas psiquiátricas como estratégia de enfrentamento das demandas cotidianas, observa-se maior prevalência entre mulheres, em razão dos papéis de gênero que lhes atribuem múltiplas funções em uma sociedade orientada pelo desempenho contínuo (Alvarenga; Dias, 2021). Esse cenário contribui para a medicalização progressiva de comportamentos cotidianos...
February 4, 2026Gustavo Santana Silva, Ludimila Freire de Castro, Luiz Felipe Cristiano Silva et al.
Este estudo teve como objetivo relatar uma experiência de vivência à comunidade Jardim Mãe de Deus, localizada no Bananal - MA, analisando a integração entre a filosofia espiritualista e o manejo de sistemas agroflorestais. A metodologia adotada possui caráter qualitativo, descritivo e exploratório, fundamentada na observação direta em campo, coleta de relatos orais da coordenadora do projeto e...
Abstract Large language models (LLMs) are increasingly consulted by individuals for support during psychedelic experiences ("trip sitting"), yet no framework exists to evaluate whether these models can accurately simulate or safely respond to altered states of consciousness. We aimed to determine if LLMs can be induced to generate narratives resembling human psychedelic experiences and to...
Indigenous Peoples have cultivated and protected natural psychoactive medicines through ceremony, kinship, and spiritual responsibility across generations, yet their long-standing contributions have often been marginalized through extractive research, commercialization, and policy exclusion. It is Indigenous communities that have stewarded and gained expertise working with psychoactive...
This article aims to reflect on the religion of Santo Daime, a tradition that emerged in the heart of the Amazon rainforest and is grounded in the ritual use of ayahuasca – an ancient indigenous brew considered an entheogen, a term of Greek origin composed of entheos ( ἔνθεος ), meaning ‘god within’, and genos ( γένος ), meaning ‘origin’ or ‘generated’. We argue for a heterotopic theology –...
January 9, 2026José Mostacero-León, Jesús Manuel Charcape Ravelo, Anthony Jordan de la Cruz Castillo et al.
The research highlights the fundamental role of magical-religious practices in the preservation, use, and transmission of ethnobotanical knowledge in Peru. These practices, deeply rooted in the Andean-Amazonian worldview, manifest themselves through the symbolic and therapeutic use of sacred plants, contributing to the continuity of the cultural and spiritual identities of indigenous...
Importance: The availability of psychedelic retreats has grown to meet the demand for access to these substances. Despite centuries of use among Indigenous communities, psychedelics can pose serious risks for some users. Objective: To determine safety precautions that retreat organizations that offer psychedelic substances currently use. Design, Setting, and Participants: This qualitative study...