, is a highly selective κ-opioid receptor agonist and a rare example of a κ-opioid receptor-mediated psychedelic drug. Preclinical work of salvinorin A has shown promising effects in neuropsychiatric animal models. However, human studies remain heterogeneous and fragmented, highlighting the need for synthesis. Thus, we conducted a systematic review to synthesize available human studies of...
People with multiple sclerosis (PwMS) often experience high rates of stress, anxiety, and depression, with low quality of life. Mindful self-compassion (MSC) training may offer a promising approach to support mental health in this population. This study explored the experiences of PwMS participating in an online MSC course as part of a feasibility trial to assess its accessibility, perceived...
Background Autonomic dysregulation is increasingly recognized as a central mechanism complicating psychotherapeutic work across anxiety, trauma-related, and mood disorders. Persistent hyperarousal (sympathetic activation) or hypoarousal (persistent parasympathetic activation or shutdown/ dissociation) may put clients out of their “window of tolerance,” thus limiting access to cognitive,...
Psychedelic decriminalization has moved from the margins of drug-policy discourse to a mainstream public health and equity conversation. This community survey reveals that people with psychedelic experience who live in areas that have decriminalized psychedelics report greater benefits of psychedelic decriminalization than adverse outcomes. In decriminalized zones, most (84.0%) participants (N...
Adolescents experienced substantial psychological distress during the COVID-19 pandemic, including elevated stress, disrupted routines, reduced peer interaction, and reduced access to in-person professional support. Mobile health (mHealth) interventions may offer accessible and scalable support for adolescents when conventional services are disrupted. This preliminary randomized controlled...
This paper examines the concepts of interbeing, mindfulness, and compassion in the teachings of Thích Nhất Hạnh, with particular emphasis on their relevance to student well-being in contemporary educational contexts. Drawing upon the framework of Engaged Buddhism, the study adopts a qualitative textual and thematic approach to analyse selected writings and teachings of Thích Nhất Hạnh. The...
Abstract: Objectives: Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes, with neuropathic pain and sensory abnormalities severely affecting patients’ quality of life. Current pharmacological treatments have limitations including insufficient efficacy and adverse reactions. Mindfulness-based interventions (MBIs) show potential in chronic pain management, yet their...
Background: Young adults experience disproportionately high levels of stress, creating significant health challenges. This demographic often underuses traditional stress management methods due to perceived ineffectiveness, inconvenience, or stigma. Given these challenges, mobile virtual reality (VR) offers a novel, engaging, and accessible alternative stress management tool that may be more...
Mindfulness interventions are considered an effective strategy for preventing mental health problems among health care workers (HCWs). While prior reviews have often included facilitator-guided or multicomponent interventions, it is unclear whether self-guided digital mindfulness interventions can also be effective without professional or in-person support. This systematic review aimed to...
Bibliometric Analysis of Meditation-Based Interventions for Mental and Behavioral Disorders: Performance, Intellectual Structure, and Thematic Evolution (2000–2024) Objectives This study will conduct a comprehensive bibliometric analysis of meditation-based interventions for mental and behavioral disorders published between 2000 and 2024. It will examine publication and citation performance,...