Depressive and anxiety symptoms are one of the leading causes of years lived with disability worldwide. Mindfulness-based interventions (MBIs) have been shown to be one of the proven treatments for improving mild and moderate cases of depression and anxiety. However, there is still a gap regarding the feasibility and effectiveness of MBIs in the real world, especially in low- and middle-income...
Salah (Islamic ritual prayer) is one of the fundamental practices of Islam and constitutes a recurring form of worship through which Muslims cultivate remembrance of Allah, spiritual consciousness, humility, discipline, and moral responsibility. Beyond its theological significance, growing academic interest has examined prayer and related religious practices in relation to psychological...
This project is a scoping review examining the current evidence base for psilocybin-assisted therapy across depression, anxiety disorders, substance use disorders, and their comorbid presentations. The review aims to map the scope of existing research, summarise reported therapeutic outcomes, and evaluate the methodological quality of the evidence base. The full study rationale, objectives,...
Auditory hallucinations (AH) represent sensory perceptions occurring in the absence of an external acoustic stimulus and are traditionally associated with psychotic disorders; however, growing evidence suggests that these phenomena may arise across a broader clinical and nonclinical spectrum. The present paper aims to examine auditory hallucinations through an integrated clinical,...
Modern life, characterised by the dominance of rationalism and materialism, has given rise to a profound spiritual crisis, manifesting itself in the form of alienation, anxiety, and a loss of meaning. This research article examines the theology of divinity in the Sufi tradition as a potential framework for addressing these contemporary issues. Focusing on two main metaphysical doctrines—Wahdat...
This scoping review aims to comprehensively map and synthesize the breadth of evidence from original research on the relationship between psilocybin and health, spanning clinical trials, epidemiological surveys, mechanistic experiments, and cross-sectional attitudinal studies. The review uses 145 references and builds its evidence map from 216 original studies with 271241797 total...
Scientific ReportsJune 14, 2026Bar Eilat Yogev, Gal Levi, Noa Efroni et al.
Alcohol consumption before trauma is a prevalent but understudied risk factor for posttraumatic stress disorder (PTSD). This study investigated whether acute ethanol exposure prior to trauma modulates PTSD-like symptom development in rats, identified hippocampal mechanisms involved, and tested an early post-trauma intervention. Adult male Sprague-Dawley rats received ethanol (1.6 g/kg, 40% v/v,...
CureusJune 13, 2026Akemini J Udoro, Yadanar Yukyi, Ali Z Ansari et al.
Psilocybin is a naturally occurring hallucinogen known to produce alterations in perception, cognition, and autonomic function through its effects on central serotonergic pathways. Products marketed as “mushroom” formulations may contain psilocybin or related psychoactive compounds despite ambiguous labeling and limited regulatory clarity, creating diagnostic challenges for clinicians in acute...
As jurisdictions across the U.S. consider enacting policies that facilitate access to psychedelics, they must determine how the desire to expand access to these substances should be weighed against the need to adequately protect safety. Oregon's psilocybin services program offers an important early case study of this balance in practice. Under the Psilocybin Services Act, adults over 21 are...
Introduction This study aims to systematically evaluate, through a systematic review and meta-analysis, the effect of esketamine on postoperative negative emotions (anxiety and depression) and cognitive function in patients undergoing general anesthesia. Methods Following PRISMA guidelines, we systematically searched PubMed, Web of Science, Embase, Cochrane Library, and CNKI to identify studies...