BMC NursingJuly 29, 2025Xiaolei Chen, Aiyan Du, Mei Yu et al.
Intensive care units (ICUs) are high-risk, high-stress environments that substantially increase the likelihood of nursing staff becoming second victims (SVs). However, current research on mindfulness interventions for ICU nurses facing SV effects is limited, particularly due to the lack of systematic intervention protocols tailored to the specific work scenarios of ICU staff. This study aims to...
OBJECTIVE: This review explores ketamine's expanding role in managing both chronic pain and mental health conditions, focusing on its pharmacologic mechanisms, clinical applications, and therapeutic potential. We assess its analgesic properties, FDA-approved application in the form of Spravato (esketamine) for depression, and off-label use for analgesia and psychiatric disorders. METHODS: A...
PharmacyJuly 21, 2025Paula S C C Castro, Kae Leopoldo, Maria Olivia Pozzolo Pedro et al.2 citations
Objective: To systematically review the scientific literature on lysergic acid amide (LSA), focusing on its physical, neurobiological, and social effects, as well as its potential risks and therapeutic uses. Methods: A systematic review was conducted across PubMed, Google Scholar, and Web of Science up to December 2023, using keywords such as "ergine," "lysergic acid amide," and "legal high."...
Depression during pregnancy is often overlooked and undertreated. Ketamine has been shown to exert prompt and sustained antidepressant effects in patients with depression, although concerns of potential neurotoxicity prohibit its use in pregnant women. Here, we aim to investigate the neurobehavioral effects of subanesthetic ketamine on pregnant mice and their offspring. We found that pregnant...
Ketamine’s rapid action and diverse physiological effects have made it an important drug in both anesthesia and mental health treatment. Clinically, it offers unique dissociative anesthetic properties, preserving stable vital signs during sedation and analgesia. Beyond its numbing effect, studies explore its influence on N-methyl-D-aspartate (NMDA) receptors and wider neurochemical systems...
Cerebrolysin (CBL), a peptide derived from pig brain, is recognized for its neuroprotective and anti-inflammatory properties. This research aimed to investigate the effects of CBL on anxiety- and depression-like behaviors, spatial memory, the tryptophan/kynurenine (TRP/KYN) pathway, and inflammation in the prefrontal cortex (PFC) of a mouse model for schizophrenia. Thirty-six male BALB/c mice...
Current microbiologyJuly 15, 2025Gokul Sudhakaran, Shreya Chakraborty, Ashok Kumar et al.2 citations
Psilocybe species, commonly known as "magic mushrooms", are a group of hallucinogenic fungi known for their psychoactive compounds such as psilocybin, psilocin, baeocystin, and norbaeocystin. These species have been the focus of scientific study due to their potential therapeutic applications, despite their classification as controlled substances in many jurisdictions. This review aims to...
Mindfulness-based interventions have provided consistent benefits for the physical and emotional wellbeing of cancer patients. However, their feasibility has not been examined in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT), particularly in the post-transplant phase. The aim of this study was to examine the feasibility and acceptability of a six-week group-based...
Given the high prevalence of psychological complications during pandemics such as COVID-19, it is imperative to identify effective psychological interventions that can improve the mental health of patients and community members. The effectiveness of mindfulness-based intervention in discharged patients with infectious respiratory diseases, particularly during pandemics, has been examined in a...
MedicineJuly 11, 2025Liyuan Fu, Minghui Mao, Chengkun Hong et al.
This study evaluates the influence of solution-focused approaches combined with mindfulness-based stress reduction (MBSR) on claustrophobia in a high-risk cohort undergoing magnetic resonance (MR) imaging. In the prospective observational 2-group study, a total of 77 patients (55% male, mean age 50.1 ± 11.9) underwent solution-focused brief therapy (SFBT) and MBSR before MR examination. The...