Depression during pregnancy is often overlooked and undertreated. Ketamine has been shown to exert prompt and sustained antidepressant effects in patients with depression, although concerns of potential neurotoxicity prohibit its use in pregnant women. Here, we aim to investigate the neurobehavioral effects of subanesthetic ketamine on pregnant mice and their offspring. We found that pregnant...
Ketamine’s rapid action and diverse physiological effects have made it an important drug in both anesthesia and mental health treatment. Clinically, it offers unique dissociative anesthetic properties, preserving stable vital signs during sedation and analgesia. Beyond its numbing effect, studies explore its influence on N-methyl-D-aspartate (NMDA) receptors and wider neurochemical systems...
Cerebrolysin (CBL), a peptide derived from pig brain, is recognized for its neuroprotective and anti-inflammatory properties. This research aimed to investigate the effects of CBL on anxiety- and depression-like behaviors, spatial memory, the tryptophan/kynurenine (TRP/KYN) pathway, and inflammation in the prefrontal cortex (PFC) of a mouse model for schizophrenia. Thirty-six male BALB/c mice...
Current microbiologyJuly 15, 2025Gokul Sudhakaran, Shreya Chakraborty, Ashok Kumar et al.2 citations
Psilocybe species, commonly known as "magic mushrooms", are a group of hallucinogenic fungi known for their psychoactive compounds such as psilocybin, psilocin, baeocystin, and norbaeocystin. These species have been the focus of scientific study due to their potential therapeutic applications, despite their classification as controlled substances in many jurisdictions. This review aims to...
Mindfulness-based interventions have provided consistent benefits for the physical and emotional wellbeing of cancer patients. However, their feasibility has not been examined in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT), particularly in the post-transplant phase. The aim of this study was to examine the feasibility and acceptability of a six-week group-based...
Given the high prevalence of psychological complications during pandemics such as COVID-19, it is imperative to identify effective psychological interventions that can improve the mental health of patients and community members. The effectiveness of mindfulness-based intervention in discharged patients with infectious respiratory diseases, particularly during pandemics, has been examined in a...
MedicineJuly 11, 2025Liyuan Fu, Minghui Mao, Chengkun Hong et al.
This study evaluates the influence of solution-focused approaches combined with mindfulness-based stress reduction (MBSR) on claustrophobia in a high-risk cohort undergoing magnetic resonance (MR) imaging. In the prospective observational 2-group study, a total of 77 patients (55% male, mean age 50.1 ± 11.9) underwent solution-focused brief therapy (SFBT) and MBSR before MR examination. The...
Innovative therapies, such as psilocybin-assisted psychotherapies, hold great promises for treating anxiety, depression, and various other mental health disorders, addressing some of the challenges faced by conventional psychiatric medicine. This study focuses on developing and validating an HPLC-DAD methodology for detecting psilocybin and psilocin in extracts from psychedelic mushrooms...
Psychological ServicesJuly 10, 2025Rachel L. Dyer, Katherine M Zimmerman, Xinxuyang Zhao et al.2 citations
In recent decades, depression and anxiety have worsened among American adults. Meditation apps may provide an accessible route for reducing these symptoms. However, many users experience barriers to persisting in their use of these apps. Prior research has identified psychosocial and practical barriers and facilitators to the use of meditation apps, as well as barriers and facilitators related...
Pediatric cardiologyJuly 2, 2025Vicki A Freedenberg, Rachel Steury, Robert Podolsky et al.
Adults with congenital heart disease (ACHD) have high rates of anxiety and depression. Strategies to manage the stress of having a chronic disease, improve coping skills and resilience can reduce these rates. To examine the effectiveness of an ACHD-specific, real-time virtual mindfulness-based behavioral intervention (MBBI) on mental health and resilience. A randomized wait-list control study...