Anxiety and stress-related disorders affect over 280 million individuals worldwide and remain inadequately treated by current pharmacotherapies, which are often limited in efficacy and tolerability. Ketamine produces rapid therapeutic effects in mood and anxiety disorders, but its clinical use is constrained by dissociative side effects and abuse liability. Ketamine metabolites, particularly (2...
Pregnancy and childbirth represent a major transition into motherhood, marked by psychosocial changes that may increase women's vulnerability to mental health difficulties such as prenatal depression, anxiety, or PTSD, in addition to physical pain. These difficulties can negatively impact maternal well-being, the mother-infant relationship, and child development. Prenatal mindfulness-based...
Background: This study compared the effects of mindfulness training (MT) and cognitive-behavioral training (CBT) on ADHD symptoms, test anxiety, and self-concept in children with ADHD and explored potential pathways of change associated with the two interventions. Methods: After a two-stage screening and eligibility confirmation procedure, 63 children with ADHD were included in the final...
DedicaJuly 6, 2026Saul de Melo Ibiapina Neres, Daisy Inocência Margarida de Lemos, Eleonardo Pereira Rodrigues et al.
A adolescência é um período crítico de desenvolvimento caracterizado por mudanças emocionais intensas, sendo a ansiedade um dos transtornos mais prevalentes nesse ciclo. O presente estudo teve como objetivo analisar a influência de práticas de Mindfulness na redução dos níveis de ansiedade em adolescentes do ensino médio de uma escola pública no interior do Piauí. Participaram 47 estudantes,...
BACKGROUND: Neurotic disorders - major depressive disorder (MDD), panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and specific phobia - have differing pharmaceutical profiles. But all, even when resistant to conventional treatment (TR), respond quickly to low dose (0.5-1.0 mg/kg I.M.) ketamine....
Self-referential processing (SRP), the mental activity of linking experiences and stimuli to the self, is fundamental to shaping identity, regulating affect, and navigating complex social environments. Disruptions in SRP are increasingly recognized as a transdiagnostic hallmark across psychiatric disorders, including schizophrenia spectrum disorders, major depressive disorder, and anxiety...
El presente artículo realiza una revisión narrativa de la literatura científica sobre la relación entre mindfulness, bienestar psicológico y desempeño académico en estudiantes de Medicina. Se efectuó una búsqueda en las bases de datos Scopus, APA PsycNET y Web of Science (WoS), abarcando el período 2011–2024, intervalo definido por la consolidación de la investigación empírica sobre mindfulness...
Annals of medicineJuly 3, 2026Zheping Chen, Yaozhu Wang, Peilin Cong et al.
Patients undergoing acoustic neuroma (AN) surgery often experience postoperative negative emotions, including anxiety, depression, and immune function suppression. This trial evaluated whether perioperative sub-anesthetic esketamine improves early postoperative negative emotions and immune function. In this single-center, double-blind, randomized trial, 84 patients scheduled for AN surgery were...
Journal of Psychoactive DrugsJuly 3, 2026Miguel Joaquim Soares Teles Couceiro, Victor José da Conceição Teixeira Amorim Rodrigues, Nuno Manuel Correia Torres
This case study explores the potential role of mystical-type experiences in ketamine-assisted psychotherapy (KAP). A patient with generalized anxiety disorder and migraines underwent four intramuscular KAP sessions (0.5-0.9 mg/kg). Outcomes were assessed using the Outcome Questionnaire-45 (OQ-45), the Hood Mysticism Scale (HMS), and interviews. Greater therapeutic gains followed sessions with...
There is growing interest in psychedelic compounds such as psilocybin, 3,4-metheylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT) given emerging research on potential uses as treatments for a variety of health conditions. The United States Food and Drug Administration (FDA) has granted multiple “Breakthrough Therapy” designations to various...