3-Methylmethcathinone (3-MMC) is a synthetic cathinone that has been scheduled in many jurisdictions after it appeared on the consumer market as a designer drug or "legal high". At present, there are no medical applications for synthetic cathinones, but in the past cathinone and other compounds that are structurally related to amphetamine have been evaluated and recognized for their intrinsic...
Psychedelic drugs including psilocybin and LSD are undergoing clinical trials for a range of psychiatric and neurological conditions, and have particularly shown substantial promise in phase 2 studies of depression. In this article we outline key knowledge gaps that may be imperative for a successful implementation of psychedelic drugs as medicines as identified by members of the European...
Although several studies and reports have shown the potential analgesic use of serotonergic psychedelics in cancer pain, phantom limb pain and cluster headache, evidence supporting their use for chronic pain is still limited. The past years have seen a considerable renewal of interest toward the therapeutic use of these compounds for mood disorders, resulting in a marked increase in the number...
Mephedrone (4-MMC, mephedrone) is a synthetic cathinone derivative included in the class of new psychoactive substances. It is commonly used simultaneously with alcohol (ethanol). The aim of the present study was to evaluate the interactions on subjective, cardiovascular and hormone effects and pharmacokinetics between mephedrone and alcohol in humans. Eleven male volunteers participated as...
Sarah Roche, Kim Pc Kuypers, Joana Wensing et al.
preprint
The therapeutic and societal promise often attributed to psychedelic drugs implies meaningful change in real-world behaviour, yet such change is rarely measured directly. Across psychedelic research, outcomes are typically assessed using symptom scales, self-reported psychological states, or retrospective judgments of change, which may capture subjective improvement but do not by themselves...
RationaleCase reports and early clinical research suggest classic psychedelics can occasion intense recall and processing of autobiographical memories. Such memory experiences have seen very little study more recently, although they may hold importance for both therapeutic effects and potential iatrogenic harms.ObjectivesThis prospective, exploratory study aimed to assess 1) the extent and...