Pharmacology, Biochemistry, and Behavior
September 1, 1975
Isaac Greenberg, D. M. Kuhn, James B. Appel
17 citations
Male albino rats were trained to respond differentially on the left or right lever in a 2-lever chamber on the basis of which drug had been given intra-peritoneally (IP) 30 min before experimentation. In 1 group 1.9 mg/kg of delta9-THC and control injections (vehicle) served as the discriminative stimuli associated with each lever and in another group the drug stimuli were 1.0 mg/kg of...
Brain Research
September 1, 1975
James P. Bennett, Solomon H. Snyder
166 citations
D-[3H]LSD binds saturably, reversibly, and with a high affinity (KD = 10 nM) to rat brain membranes. The association and dissociation rates of binding are temperature dependent and fastest at 37 degrees C. Binding is enriched in crude microsomal (P3) membranes. D-[3H]LSD binding is stereospecific as L-LSD, the psychotropically inactive enatiomer, is 1000 times weaker than D-LSD as a displacing...
Journal of Pharmacology and Experimental Therapeutics
June 1, 1975
D. Gallager, George K. Aghajanian
83 citations
The effects of d-lysergic acid diethylamide (LSD) and chlorimipramine (CIMI) on the firing rate of serotonergic (5-HT) neurons and on the in vivo efflux of 5-HT were investigated in parallel. A cerebroventricular perfusing technique was used to measure the efflux of 3-H-5-HT formed in vivo from 3-H-tryptophan. Impulse flow in serotonergic neurons was monitored by single unit recording from...
Pharmacology, Biochemistry, and Behavior
1975
Mark A. Geyer, J D Warbritton, D B Menkes et al.
34 citations
Rat startle responses to air puffs were monitored in a stabilimeter during the intraventricular infusion of various doses of 5-hydroxytrptamine (5-HT) or the putative hallucinogenic congener of 5-HT, 5-hydroxy-N, N-dimethyltrytamine (5-HDMT) or saline. Qualitativity opposite effects were observed, with 5-HT producing a dose-dependent decrease in responsivity and 5-HDMT increasing the magnitude...
JOURNAL OF INDIAN AND BUDDHIST STUDIES
1974
Yoshiharu Akishige
Modern psychology has treated the concept of Ego, hitherto regarded as something special, as a mere gestalt defined by the field of consciousness like all other objects.This is a great achievement of the modern psychology.Modern psychology has a great wealth of knowledge about the constancy of the world of perception, which includes the Ego, and has elucidated its laws.Accrding to these laws,...
Journal of Psychedelic Drugs
1974
Ibrahim Turek, Robert A. Soskin, Albert A. Kurland
59 citations
(1974). Methylenedioxyamphetamine (MDA)–Subjective Effects. Journal of Psychedelic Drugs: Vol. 6, No. 1, pp. 7-14.
Archives of General Psychiatry
June 1, 1973
Charles Savage
150 citations
A controlled investigation was made of the rehabilitative efficacy of brief residential psychedelic (LSD) psychotherapy with chronic heroin abusers. Seventy-eight volunteer addict inmates from Maryland correctional institutions were randomly assigned to the following: a treatment condition–psychedlic therapy (incorporating one high-dose LSD administration) during a six weeks residence in a...
Journal of Neurochemistry
October 1, 1972
D. G. Grahame‐Smitha
Abstract— In rats treated with a monoamine oxidase inhibitor, (tranylcypromine), L‐ tryptophan produces a stereotyped syndrome of hyperactivity and hyperpyrexia due to an increased rate of brain serotonin (5‐hydroxytryptamine) synthesis. Pretreatment of rats with intraperitoneal injections of cycloheximide, acetoxycycloheximide, emetine and dehydroemetine and of mice with puromycin inhibited...
Science
August 25, 1972
Linda A. Dykstra, James B. Appel
A stimulus generalization procedure was used to investigate the effects of LSD on sensitivity to auditory stimuli in rats. The shape of the generalization gradient was changed after administration of the drug only with a dose which produced decreases in relatively high rates of responding.
The Journal of Nervous and Mental Disease
June 1, 1972
William F. Kiely, Ernst Gellhorn
150 citations
The relationship of the trophotropic and ergotropic systems of autonomic-somatic integration and their relevance to a variety of emotional states and levels of consciousness is reviewed. The importance of proprioceptive afferent feedback to the reticular formation and hypothalamus for the maintenance of ergotropic responsivity is indicated together with the beneficial clinical effects of...