European Journal of Pharmacology
June 18, 1991
Isabelle M Maisonneuve, R W Keller, Stanley D Glick
127 citations
Ibogaine, an indolalkylamine, has been claimed to be effective in abolishing drug craving in heroin and cocaine addicts. The present study used in vivo microdialysis to determine the effects of ibogaine on extracellular levels of dopamine (DA) and its metabolites and the effects of ibogaine pretreatment on morphine stimulation of brain DA systems. Acutely, ibogaine (40 mg/kg i.p.) decreased...
Alcoholism Treatment Quarterly
May 6, 1991
David F. O'Connell
5 citations
Previous research has shown that transcendental meditation (TM) can be an effective technique to treat chemical dependency and associated psychological dysfunctions. In this paper the author explores the use of TM as an adjunctive treatment of chronic relapse through a case report and in light of previous research on relapse determinants. Practical considerations in the use of TM as an...
Theory & Psychology
May 1, 1991
H. Flohr
42 citations
A hypothesis on the physiological conditions for the occurrence of phenomenal states is presented. It is suggested that the presence of phenomenal states depends on the rate at which neural assemblies are formed. Unconsciousness and various disturbances of phenomenal consciousness occur if the assembly formation rate is below a certain threshold level; if this level is surpassed, phenomenal...
European Journal of Pharmacology
April 3, 1991
Stanley D Glick, K Rossman, S Steindorf et al.
195 citations
Ibogaine, a naturally occurring alkaloid, has been claimed to be effective in treating addition to opiate and stimulant drugs. As a preclinical test of this claim, the present study sought to determine if ibogaine would reduce the intravenous self-administration of morphine in rats. Ibogaine dose dependently (2.5-80 mg/kg) decreased morphine intake in the hour after ibogaine treatment (acute...
Pharmacology, Biochemistry, and Behavior
February 1991
T D Steele, W K Brewster, M P Johnson et al.
To assess the potential involvement of metabolism of 3,4-methylenedioxymethamphetamine (MDMA) to the catechol alpha-methylepinine in producing serotonergic neurotoxicity, we attempted to correlate aspects of this reaction with the neurotoxicity profile of MDMA. In contrast to the stereoselectivity of S-(+)-MDMA in causing persistent declines in rat brain 5-hydroxyindole levels, no...
Life Sciences
1991
John R. Lever, Ursula Scheffel, J L Musachio et al.
Radioiodinated D-(+)-N1-ethyl-2-iodolysergic acid diethylamide ([125I]-EIL) has been evaluated as a ligand for in vitro and in vivo studies of cerebral serotonin 5-HT2 receptors. [125I]-EIL exhibited high affinity (KD = 209 pM) for 5-HT2 receptors with a high degree of specific binding (80-95%) in membranes from rat prefrontal cortex. The regional distribution of [125I]-EIL binding in vivo to...
The American Journal of Psychology
1991
Piercarla Cicogna, Corrado Cavallero, Marino Bosinelli
70 citations
Upon nighttime experimental awakening of 27 subjects in four sleep conditions (sleep onset early; sleep onset late; Stage 2; and rapid eye movement, REM, sleep), 108 dream reports and their association reports were collected. Dream reports were analyzed for length (temporal units) and content categories (continuity; implausibility; presence of the dreamer [i.e., "the self"], a setting,...
1991
Francisco J. Varela, Evan Thompson, Eleanor Rosch
Part 1 The departing ground: a fundamental circularity - in the mind of the reflective scientist - an already-given condition, what is cognitive science?, cognitive science within the circle, the theme of this book what do we mean "Human Experience"? - science and the phenomenological tradition, the breakdown of phenomenology, a non-western philosophical tradition, examining experience with a...
Scripta Instituti Donneriani Aboensis
1991
Åke Hultkrantz
Shamanism has not been restricted to northern Eurasia and the American Arctic, although it was here that it received its most remarkable forms. It is thus central to consider whether the drum is an integrative part of shamanism and should be examined against a general, and not a regional background. It is important to distinguish Arctic shamanism from other forms of shamanism. Arctic shamanism...
Psychopharmacology
1991
G E Evoniuk, R P Hertzman, Phil Skolnick
A simple and rapid method for detecting the behavioral effects of phencyclidine and related dissociative anesthetics is described. Dissociative anesthetics such as phencyclidine (PCP) and dizolcipine, which bind with high affinities at N-methyl-D-aspartate (NMDA) coupled cation channels ("PCP receptors"), produced a dose-related increase in the percentage of mice that fell from a 1.5 cm deep...