Life Sciences
1992
Henry Sershen, L G Harsing, Audrey Hashim et al.
33 citations
The effect of ibogaine hydrochloride on locomotor stimulation induced by d-amphetamine sulfate was tested in male C57BL/6By mice and in female Sprague-Dawley rats. In mice, locomotor stimulation induced by d-amphetamine at 1 or 5 mg/kg s.c. was reduced by prior administration of one or two injections of ibogaine (40 mg/kg), given 2 or 18 hours earlier. This reduction in locomotor activity...
Journal of Pharmacology and Experimental Therapeutics
November 1, 1991
J F Nash, J Brodkin
The effect of dopamine (DA) and serotonin (5-HT) uptake inhibitors on 3,4-methylenedioxymethamphetamine (MDMA)-induced increase in DA efflux was studied using in vivo microdialysis. MDMA was infused directly into the anterolateral striatum via the dialysis probe. The local administration of MDMA produced a dose- and time-dependent increase in the extracellular concentration of DA in the...
Pharmacology, Biochemistry, and Behavior
October 1991
J I Székely, L G Sharpe, J H Jaffe
The behavioral effects of dextromethorphan (DM), dextrorphan (DO) and phencyclidine (PCP) were compared in rats. DO (15-120 mg/kg) was similar to PCP (1.25-20 mg/kg) in inducing dose-dependent locomotor hyperactivity, stereotypy and ataxia. DM (15-120 mg/kg) induced moderate hyperactivity only at the higher doses about 45 min after treatment. DM and DO modified the locomotor facilitation...
Behavioural Pharmacology
September 1, 1991
Donald A. Overton
89 citations
Drug-induced state dependent learning (SDL), as well as similar effects on memory retrieval exercised by physiological states, have been known since 1830. Before 1950, understanding of this area derived primarily from clinical descriptions of somnambulism, dream recall, fugue states, and cases of multiple personality. After 1950, experimental demonstrations of the properties of SDL and drug...
Culture, Medicine, and Psychiatry
September 1, 1991
V Skultans
27 citations
The anthropological literature on spirit possession cults offers a distinction between voluntary possession or mediumship and involuntary possession or illness. Fieldwork was carried out in a Mahanubhav healing temple. Contradictory interpretations of trance and affliction were found to be held by the different temple inhabitants. Beliefs about the nature of spiritual affliction, its...
Synapse
August 1, 1991
George Battaglia, John Sharkey, Michael J. Kuhar et al.
113 citations
Abstract The Widely abused “designer” durg MDMA (3,4‐methylenedioxymethamphetamine) has been shown to caused marked and long‐lasting changes in brain serotonergic systems. The present study uses quantitative in vitro autoradiography of 3 H‐paroxetine labeled 5‐HT uptake sites to assess the time‐dependent effects of MDMA on 5‐HT neurons in specific neuroanatomic loci. Following treatment with...
American Journal of Psychotherapy
July 1, 1991
Greg Bogart
67 citations
This article has explored research to date concerning the efficacy of introducing meditation into the therapeutic setting. I have presented the views of proponents and critics of the relaxation model of meditation and of theories describing the cognitive changes brought about by meditation--for example, Deikman's theory of the deautomatization of consciousness and Delmonte's view that...
European Journal of Pharmacology
June 18, 1991
Isabelle M Maisonneuve, R W Keller, Stanley D Glick
127 citations
Ibogaine, an indolalkylamine, has been claimed to be effective in abolishing drug craving in heroin and cocaine addicts. The present study used in vivo microdialysis to determine the effects of ibogaine on extracellular levels of dopamine (DA) and its metabolites and the effects of ibogaine pretreatment on morphine stimulation of brain DA systems. Acutely, ibogaine (40 mg/kg i.p.) decreased...
Alcoholism Treatment Quarterly
May 6, 1991
David F. O'Connell
5 citations
Previous research has shown that transcendental meditation (TM) can be an effective technique to treat chemical dependency and associated psychological dysfunctions. In this paper the author explores the use of TM as an adjunctive treatment of chronic relapse through a case report and in light of previous research on relapse determinants. Practical considerations in the use of TM as an...
Theory & Psychology
May 1, 1991
H. Flohr
42 citations
A hypothesis on the physiological conditions for the occurrence of phenomenal states is presented. It is suggested that the presence of phenomenal states depends on the rate at which neural assemblies are formed. Unconsciousness and various disturbances of phenomenal consciousness occur if the assembly formation rate is below a certain threshold level; if this level is surpassed, phenomenal...