L G Harsing

2 papers in the library · 59 citations · publishing 1992-1994

Papers

Ibogaine reduces amphetamine-induced locomotor stimulation in C57BL/6By mice, but stimulates locomotor activity in rats.

Life Sciences January 1, 1992 H Sershen, L G Harsing, A Hashim et al. 33 citations

Ibogaine hydrochloride reduced the locomotor stimulation caused by low-to-moderate doses of d-amphetamine in male mice, an effect that lasted two days, but did not block the effect of a high dose. A lower dose of ibogaine was ineffective. Ibogaine decreased striatal dopamine levels by 30%, while d-amphetamine increased them by 26%. In rats, ibogaine pretreatment paradoxically increased d-amphetamine-induced locomotion, indicating species specificity. The findings suggest ibogaine can modulate dopamine-related behavioral effects in a dose- and species-dependent manner.

DOI: 10.1016/0024-3205(92)90498-e Full text

Evidence that ibogaine releases dopamine from the cytoplasmic pool in isolated mouse striatum.

Journal of neural transmission. General section January 1, 1994 L G Harsing, H Sershen, A Lajtha 26 citations

Ibogaine increases the release of dopamine from mouse striatum in a concentration-dependent way, primarily from the cytoplasmic pool rather than from vesicles, and this release is not regulated by presynaptic autoreceptors. The effect is reduced by dopamine uptake inhibitors but not by removing calcium or blocking sodium channels. Ibogaine does not affect dopamine uptake or retention. The dopamine-releasing action may contribute to its hallucinogenic effects observed in African ritual practices.

DOI: 10.1007/bf01294788 Full text