Addiction: all studies (page 78) - The Consciousness Library

Treadmill Exercise Training Ameliorates Apoptotic Cells and DNA Oxidation in the Cerebral Cortex of Rats Exposed to Chronic Ketamine Abuse.

Addiction Biology March 1, 2025 Salar Sabziparvar, Kazem Khodaei, Javad Tolouei Azar 1 citation

Ketamine abuse damages brain function and structure, increasing reactive oxygen species and apoptosis in the cerebral cortex, but moderate-intensity continuous training (MICT) can enhance antioxidant defences and reduce apoptosis. Therefore, we aimed to answer whether MICT can reduce the side effects of chronic ketamine abuse. 24 Wistar rats were split into control (CON), ketamine abuse (KET),...

DOI: 10.1111/adb.70025 Full text Ketamine Brain health Apoptosis Drug abuse +4

Over-the-counter Psychosis: A Systematic Review of the Misuse of Antihistamines, Cough Medicines, and Decongestants and the Risk of Developing Psychosis

Current Neuropharmacology February 20, 2025 Alessio Mosca, Stefania Chiappini, Gianluca Mancusi et al. 3 citations

BACKGROUND: The widespread availability and accessibility of over-the-counter (OTC) medicines play a vital role in modern healthcare systems, enabling individuals to manage minor health concerns independently. However, certain OTC medications possess pharmacological properties that render them susceptible to misuse and abuse, including stimulants, laxatives, sedatives, and opiate-containing...

DOI: 10.2174/011570159x344365250114064248 Full text Addiction Dextromethorphan Codeine Psychosis +8

Long-Term Mental Health and Wellbeing Outcomes Associated with Naturalistic Ayahuasca Consumption.

Journal of Psychoactive Drugs February 20, 2025 Broc A. Pagni, Andreas Halman, Jerome Sarris et al. 7 citations

The durability of ayahuasca's effects on mental health and the influence of clinical diagnoses on therapeutic response is unclear. Adults with no prior exposure to ayahuasca (n = 66) participating in neo-shamanic ayahuasca ceremonies completed questionnaires at baseline, 7 days, and 1, 6, and 12 months. Mixed models were used to characterize temporal trajectories in mental health, alcohol and...

DOI: 10.1080/02791072.2025.2465800 Full text DMT Anxiety Depression Addiction +10

Abdominal Pain and Dysuria Secondary to Chronic Recreational Ketamine Use: A Case Report on K-cramps.

Cureus February 1, 2025 Eric Boccio, Jason Haidar, Michael Thiefault et al.

Medical and recreational ketamine use is increasing in the United States; however, little is known regarding the side effects associated with chronic, frequent, and high-dose use. The lack of emergency physician awareness regarding ketamine-induced abdominal pain, nausea, vomiting, and dysuria, collectively and colloquially known as K-cramps, results in delayed recognition, underreporting, and...

DOI: 10.7759/cureus.78422 Full text Substance use disorder Abdominal pain Case report Dysuria +6

Self-reported experiences and perspectives on using psychedelics to manage opioid use among participants of two Reddit communities.

Addiction January 16, 2025 Noa Krawczyk, Megan Miller, Emma Yuanqi Gu et al. 2 citations

The opioid crisis continues to exert a tremendous toll in North America, with existing interventions often falling short of addressing ongoing needs. Psychedelics are emerging as a possible alternative therapy for mental health and substance use disorders. This study aimed to gather insights on how people use or are considering using psychedelics to manage opioid use disorder (OUD), how these...

DOI: 10.1111/add.16767 Full text Ibogaine Opioid use disorder Psilocybin Psychedelics hallucinogens +12

Abnormal developmental of hippocampal subfields and amygdalar subnuclei volumes in young adults with heavy cannabis use: A three-year longitudinal study.

Progress in Neuro-Psychopharmacology and Biological Psychiatry January 10, 2025 Xueyi Zhang, Zhengju Chen, Benjamin Becker et al.

Differences in the volumes of the hippocampus and amygdala have consistently been observed between young adults with heavy cannabis use relative to their non-using counterparts. However, it remains unclear whether the subfields of these functionally and structurally heterogenous regions exhibit similar patterns of change in young adults with long-term heavy cannabis use disorder (CUD). This...

DOI: 10.1016/j.pnpbp.2024.111156 Full text Addiction Amygdala Cannabis use Longitudinal analysis +4

Alternative therapy for neurological and psychiatric disorders using psilocybin

2025 Henrique Tofoli Vieira Machado, Geovana Mendes de Seixas, L. Silva et al.

Introduction: In recent years, psilocybin has been explored as an alternative therapy for neurological and psychiatric disorders, such as depression, anxiety, post-traumatic stress disorder (PTSD), and substance dependence. Studies suggest that when administered under professional supervision, psilocybin can offer relief for patients with treatment-resistant disorders. Objective: The aim of...

DOI: 10.5327/1516-3180.cpn.1123 Psilocybin Anxiety Addiction Hallucinogen +5

Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research.

American Journal of Psychiatry 2025 Roger S McIntyre, Angela T H Kwan, Rodrigo B. Mansur et al. 23 citations

During the past decade, there has been extraordinary public, media, and medical research interest in psychedelics as promising therapeutics for difficult-to-treat psychiatric disorders. Short-term controlled trial data suggest that certain psychedelics are effective and safe in the treatment of major depressive disorder, treatment-resistant depression, and posttraumatic stress disorder....

DOI: 10.1176/appi.ajp.20230902 Full text Alcohol use disorder Depressive disorders Methodology Psychedelics

On the wings of Icarus - the need for transcendence in addictive diseases.

Frontiers in Psychiatry 2025 Human-Friedrich Unterrainer 4 citations

This essay employs the Icarus myth as a metaphor to examine the role of transcendence in addiction. Icarus' disregard for boundaries, driven by his quest for transcendence, mirrors the behavior of individuals with addictive tendencies. Addiction, a chronic disorder marked by compulsive substance use or behaviors, is characterized by loss of control, tolerance, withdrawal, and life disruptions....

DOI: 10.3389/fpsyt.2025.1563871 Full text Addiction Greek mythology Attachment Emotion regulation +4

Characterizing the therapeutical use of ketamine for adolescent rats of both sexes: Antidepressant-like efficacy and safety profile.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jordi Jornet-Plaza, Sandra Ledesma-Corvi, M Julia García-Fuster 6 citations

While ketamine was approved for treatment-resistant depression in adult patients, its efficacy and safety profile for adolescence still requires further characterization. In this context, prior preclinical studies have shown that sub-anesthetic doses of ketamine during adolescence exert antidepressant-like effects in rodents in a dose- and sex-dependent manner. However, additional studies...

DOI: 10.1016/j.biopha.2024.117781 Full text Addiction Adolescence Cognition Depression treatment +4