July 12, 2026
Fahd François Hilal, Méléna Dreinaza, Quentin Lebel et al.
Background and Purpose: Ketamine has emerged as a promising treatment candidate for alcohol use disorder (AUD), yet whether its S- and R-enantiomers differentially regulate ongoing binge-like alcohol self-administration remains unknown. We compared the acute and repeated effects of S- and R-ketamine in a chronic binge-like, front-loaded operant alcohol self-administration paradigm. Experimental...
Expert Opinion on Drug Discovery
July 4, 2026
Christopher D. Verrico, Lynnette A. Averill, Cameron J Moore et al.
INTRODUCTION: Ibogaine is a naturally occurring indole alkaloid with suggested therapeutic potential across substance use disorders, trauma-related conditions, mood disorders, and suicidality. However, its clinical translation has been hindered by safety concerns, regulatory barriers, and uncertainty regarding its complex pharmacology. Recent interest has surged in developing ibogaine analogs...
Revista CienciaUANL
July 1, 2026
Armando Ordaz‐hernández, M. Corona-Ramírez, Israel Jesús Orlando Guerrero
La psilocibina, presente en los “hongos mágicos”, y la 5-MeO-DMT, secretada por el sapo Incilius alvarius, fueron empleadas ancestralmente en rituales espirituales en México. Hoy, la ciencia las reconoce como terapias prometedoras contra depresión, ansiedad, estrés postraumático y adicciones resistentes a tratamientos convencionales. Actúan sobre receptores de serotonina y estimulan la...
Journal of Psychoactive Drugs
June 19, 2026
Carla J. Berg, Darcey M. Mccready, Cassidy R Loparco et al.
= 26.38, ~50% past-month cannabis use by design) completed an online survey. Multivariable regression assessed sociodemographics, mental health, and adverse childhood events (ACEs) in relation to: (1) past-year psychedelic use; and (2) among those reporting lifetime use: (a) lifetime microdosing and (b) use motives. Lifetime and past-year psychedelic use were 27.7% and 11.9% (commonly...
Leiden Repository
June 18, 2026
W.c. Naber
This dissertation explored the factors underlying the “waves” of cluster headache and investigated strategies to reduce disease burden and improve quality of life. The first part focused on disease mechanisms, prognosis, and patient experiences. Long-term remission was associated with episodic disease, later onset age, more painful attacks, and smoking cessation, suggesting a multifactorial...
Research Square
June 17, 2026
Martijn Arns, Kenneth Shinozuka, Joseph P Barsuglia
preprint
Abstract Ibogaine has shown early therapeutic promise for substance use disorders (SUD) and post-traumatic stress disorder in veterans, but concerns about treatment-associated cardiac arrhythmia and death have constrained clinical development. Whether this risk is uniform across indications or concentrated in specific populations is unknown. We conducted a retrospective multisite study of...
Frontiers in Psychiatry
June 10, 2026
Justyna Śniadach, Sylwia Szymkowiak, Przemysław Osip et al.
Background: Cannabis use has increased across Europe over the last decade, accompanied by growing availability of high-potency THC products and rising psychiatric presentations. Despite these trends, European countries differ substantially in monitoring systems, clinical preparedness and public health responses. These disparities are especially visible between Western Europe, which has more...
Journal of Affective Disorders
June 8, 2026
Dian‐jeng Li, Tien-Wei Hsu, Te-Chang Changchien et al.
Little is known about esketamine's effectiveness for patients with major depressive disorder (MDD) comorbid substance use disorders (SUD). We conducted a retrospective cohort study using the TriNetX US Collaborative Network, including adults aged ≥18 years with MDD. Three propensity-score-matched (1:1) cohorts were defined based on treatment: esketamine, antidepressant-only, and repetitive...
Myanmar Medical Journal
June 4, 2026
Aung Kyaw Thu, Zaw Hlaing Toe, Si Thu Linn
“Happy water” has been gaining popularity among party goers. The effect of consuming this drug can be fatal. Two patients of “Happy water” overdose were admitted for reduced level of consciousness after enjoying a farewell party at nightclub. Urine for toxicology screening was found to be positive for methylenedioxymethamphetamine (MDMA), methamphetamine, diazepam and tramadol. “Happy water” is...
European Psychiatry
June 1, 2026
V. Fournier, André Kuntz, Rafik Bouzegaou et al.
Introduction As the number of treatment resistant patient in the psychiatric field has been growing over the last decades, there is a clear need for new therapeutic options. Over several years, the field of psychedelic assisted psychotherapy has been rapidly developing. In this scope ketamine assisted psychotherapy (KAP) has come into psychiatric use to treat depression resistant depression,...