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Pot Politics September 21, 2006 Elliot N. Dorff
Abstract: This chapter approaches the issue of marijuana use from a Jewish perspective. The Torah demands that Jews become “a kingdom of priests and a holy nation.” The Jewish tradition uses wine to sanctify holidays and marriages; it does not use marijuana for those purposes. Still, Judaism allows Jews to ingest many things that are not intrinsically holy as part of the effort to fulfill the...
European Journal of Pharmacology September 18, 2006 Trentini F John, Larry G French, Joseph S Erlichman 76 citations
Salvia divinorum is a hallucinogenic plant used by the Mazatec Indians of Mexico for traditional spiritual ceremonies. The active constituent, salvinorin A, induces profound hallucinations, however the biological mechanism for this action is not known. Affinity-binding studies suggest that the biologic activity of salvinorin A involves the kappa-opioid receptor. The purpose of this study was to...
Clinical cardiology September 1, 2006 Satish Sivasankaran, Suzanne Pollard-Quintner, Rajesh Sachdeva et al.
Background: Chronic stress is estimated to increase the risk of cardiovascular (CV) events two-fold. Although stress reduction has been linked to a reduction in CV events, little is known regarding its exact mechanism of benefit. Hypothesis: Yoga and meditation will improve parameters of endothelial function. Methods: We examined the effects of yoga and meditation on hemodynamic and laboratory...
Bioorganic & Medicinal Chemistry Letters September 1, 2006 Cécile Béguin, Michele R Richards, Jian-Guo Li et al.
kappa-opioid receptor ligands have raised interest for their apparent effects on mood. The potent and selective kappa-agonist salvinorin A has short-lasting (15min) depressive-like effects in rats in behavioral models used to study mood disorders. Two series of salvinorin derivatives modified at C(2) and C(18), respectively, were synthesized and their kappa-opioid receptor affinities,...
Journal of Neurochemistry August 15, 2006 Jason C. Parrish, David E. Nichols 61 citations
To date, several studies have demonstrated that phospholipase C-coupled receptors stimulate the production of endocannabinoids, particularly 2-arachidonoylglycerol. There is now evidence that endocannabinoids are involved in phospholipase C-coupled serotonin 5-HT(2A) receptor-mediated behavioral effects in both rats and mice. The main objective of this study was to determine whether activation...
BMJ August 3, 2006 Michael Gossop 8 citations
This week the House of Commons Select Committee on Science and Technology published the report of its inquiry on the classification of illegal drugs in the United Kingdom.1 The report high-lighted glaring anomalies in the classification of illegal drugs into classes A, B, and C and reflected a broad agreement that the current system is not fit for purpose. The committee also reported...
Cognition August 2006 Michael Snodgrass, Howard Shevrin
Although the veridicality of unconscious perception is increasingly accepted, core issues remain unresolved [Jack, A., & Shallice, T. (2001). Introspective physicalism as an approach to the science of consciousness. Cognition, 79, 161-196], and sharp disagreement persists regarding fundamental methodological and theoretical issues. The most critical problem is simple but tenacious-namely, how...
Annals of the New York Academy of Sciences August 1, 2006 Sergio Abanades, Magı́ Farré, Mireia Segura et al. 124 citations
Despite gamma-hydroxybutyrate (GHB) therapeutic uses and the increasing concern about its toxicity, few studies have addressed GHB dose-related effects under controlled administration and their relationship with its pharmacokinetics. The study design was double-blind, randomized, crossover, and controlled. As a pilot pharmacology phase I study, increasing doses of GHB were given. Single oral...
Physiology & Behavior August 1, 2006 María E. Reverón, Esther Y. Maier, Christine L. Duvauchelle 23 citations
Hyperthermia and hyperlocomotor activity are commonly reported acute effects of high dose, experimenter-delivered 3,4-methylenedioxymethamphetamine (MDMA). The current investigation was performed to determine short- to long-term physiological and behavioral changes induced by moderate intake MDMA self-administration. In the present study, rats self-administered MDMA (approx. 2.0-7.0 mg/kg/day)...
Journal of Pharmacology and Experimental Therapeutics August 1, 2006 Michael Ansonoff, Jiwen Zhang, Traci A Czyzyk et al. 101 citations
Salvia divinorum is a natural occurring hallucinogen that is traditionally used by the Mazatec Indians of central Mexico. The diterpene salvinorin A was identified as an active component of S. divinorum over 20 years ago, but only recently has biochemical screening indicated that a molecular target of salvinorin A in vitro is the kappa-opioid receptor. We have examined whether salvinorin A, the...