Brain
January 2006
Juergen Fell, Guillén Fernández, Martin T Lutz et al.
Compared with waking state attention, volition and semantic processing play a minor role during sleep. Thus, investigating declarative memory formation during sleep may allow us to isolate mnemonic core processes. The most feasible approach to memory formation during sleep is the analysis of dream memories. Lesion and imaging studies have demonstrated that encoding of declarative memories, i.e....
Neuroscience
2006
Julie Salzmann, C Canestrelli, Florence Noble et al.
3,4-Methylenedioxymethamphetamine (ecstasy), a widely used recreational drug with psychoactive properties, induces both serotonin and dopamine release in the brain. However, little is known about its intracellular effects. We previously showed that 3,4-methylenedioxymethamphetamine rewarding effects in mice were dependent upon extracellular signal-regulated kinase activation and that dorsal...
Journal of Pharmacology and Experimental Therapeutics
January 2006
João Paulo Capela, Andreas Meisel, Artur Reis Abreu et al.
3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a widely abused, psychoactive recreational drug. There is growing evidence that the MDMA neurotoxic profile may be highly dependent on both its hepatic metabolism and body temperature. Metabolism of MDMA involves N-demethylation to 3,4-methylenedioxyamphetamine (MDA), which is also a drug of abuse. MDMA and MDA are O-demethylenated to...
UC Research Repository
2006
Elisabeth Jane Cooper
Plotinus (3rd century C.E.) and Afdal al-Din Kashani (12th century C.E.) each posit that the highest human goal is to become aware of the ultimate unity of reality. Both are rational mystics, and each describes a rigorous moral and intellectual training through which alone a human can achieve the goal. Seldom studied as a field in itself, rational mysticism offers a vision of philosophy that...
Reviews in the Neurosciences
2006
Bigna Lenggenhager, S T Smith, Olaf Blanke
Embodiment, the sense of being localized within one's physical body, is a fundamental aspect of the self. Recent research shows that self and body processing as well as embodiment require distinct brain mechanisms. Here, we review recent clinical and neuroimaging research on multisensory perception and integration as well as mental imagery, pointing out their importance for the coding of...
Pharmacology, Biochemistry, and Behavior
2006
William E Fantegrossi, A W Harrington, C L Kiessel et al.
144 citations
Few studies have examined the effects of 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) in vivo. In these studies, 5-MeO-DIPT was tested in a drug-elicited head twitch assay in mice where it was compared to the structurally similar hallucinogen N,N-dimethyltryptamine (N,N-DMT) and challenged with the selective serotonin (5-HT)2A antagonist M100907, and in a lysergic acid diethylamide (LSD)...
The Journal of Comparative Neurology
2006
Csaba Ádori, Rómeó D. Andó, Gábor G. Kovács et al.
51 citations
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") causes long-term disturbance of the serotonergic system. We examined the temporal, spatial, and cellular distribution of three molecular chaperones, Hsp27, Hsp72, and Hsp90, 3 and 7 days after treatment with 7.5, 15, and 30 mg/kg single intraperitoneal (i.p.) doses of MDMA in Dark Agouti rat brains. Furthermore, we compared the immunostaining...
Neurogastroenterology & Motility
2006
Raffaele Capasso, Francesca Borrelli, F Capasso et al.
56 citations
Salvia divinorum is a widespread hallucinogenic herb traditionally employed for divination, as well as a medicament for several disorders including disturbances of gastrointestinal motility. In the present study we evaluated the effect of a standardized extract from the leaves of S. divinorum (SDE) on enteric cholinergic transmission in the guinea-pig ileum. SDE reduced electrically evoked...
Journal of Neuroscience
December 14, 2005
Susana Mato, David Robbe, Nagore Puente et al.
Alterations of long-term synaptic plasticity have been proposed to participate in the development of addiction. To preserve synaptic functions, homeostatic processes must be engaged after exposure to abused drugs. At the mouse cortico-accumbens synapses, a single in vivo injection of Delta9-tetrahydrocannabinol (THC) suppresses endocannabinoid-mediated long-term depression. Using biochemical...
December 7, 2005
S. Schwartz, Thanh Dang-Vu, A. Ponz et al.
Sleep and dream research has recently been invigorated by convergent data from complementary neuropsychological sources such as brain-imaging studies of normal sleep, clinical investigations of dream disorders in brain-damaged patients and analyses of dream reports from healthy individuals. Here we show that by adopting a neuropsychological approach to dream phenomenology we can gain important...