The antinociceptive effect of salvinorin A in mice.
European Journal of Pharmacology September 18, 2006 Trentini F John, Larry G French, Joseph S Erlichman 76 citations
Salvia divinorum is a hallucinogenic plant used by the Mazatec Indians of Mexico for traditional spiritual ceremonies. The active constituent, salvinorin A, induces profound hallucinations, however the biological mechanism for this action is not known. Affinity-binding studies suggest that the biologic activity of salvinorin A involves the kappa-opioid receptor. The purpose of this study was to...