Addiction Biology
January 2011
Peter J Winsauer, Jill M Daniel, Catalin M Filipeanu et al.
Abuse of Δ⁹-THC by females during adolescence may produce long-term deficits in complex behavioral processes such as learning, and these deficits may be affected by the presence of ovarian hormones. To assess this possibility, 40 injections of saline or 5.6 mg/kg of Δ⁹-THC were administered i.p. daily during adolescence to gonadally intact or ovariectomized (OVX) female rats, yielding four...
Frontiers in Behavioral Neuroscience
2011
Eva María Marco
139 citations
Public concern on mental health has noticeably increased given the high prevalence of neuropsychiatric disorders. Cognition and emotionality are the most affected functions in neuropsychiatric disorders, i.e., anxiety disorders, depression, and schizophrenia. In this review, most relevant literature on the role of the endocannabinoid (eCB) system in neuropsychiatric disorders will be presented....
PLoS One
2011
Joost Wiskerke, Nicky Stoop, Dustin Schetters et al.
It is well known that acute challenges with psychostimulants such as amphetamine affect impulsive behavior. We here studied the pharmacology underlying the effects of amphetamine in two rat models of impulsivity, the 5-choice serial reaction time task (5-CSRTT) and the delayed reward task (DRT), providing measures of inhibitory control, an aspect of impulsive action, and impulsive choice,...
VCU Scholars Compass
2011
D. Matthew Walentiny
Cannabinoid agonists (e.g., THC) dose-dependently decrease locomotor activity and body temperature and produce antinociception and catalepsy. Drugs that produce this tetrad of effects within a limited dose range are likely to function as CB1 receptor agonists. A structure activity relationship study from our laboratory investigating analogs of the CB1 antagonist rimonabant revealed that certain...
2011
Bridget Simonson
1 citation
Classic kappa opioid receptor (KOPr) agonists have shown anti-addictive properties in rat models of addiction (Heidbreder et al. 1998; Schenk et al. 1999; Sun et al. 2010), and this has been shown to be partially through modulation of dopamine and serotonin in the synapse (Thompson et al. 2000; Zhang et al. 2004; Zakharova et al. 2008a). However, they have side effects such as depression and...
Biological Psychiatry
January 1, 2011
Yanhui Liao, Jinsong Tang, Philip R. Corlett et al.
Use of ketamine as a recreational drug is spreading rapidly among young people all over the world. Epidemiological studies have linked chronic ketamine use with a number of problems, including cognitive impairments, bladder dysfunction, and ketamine-related death. However, little is known about the long-term effects of ketamine use on brain structure and function. We used voxel based...
Figshare
2011
Aashish S Morani
1 citation
Rationale: Kappa opioid receptor (KOPr) activation by traditional agonists has been shown to produce anti-addiction behaviours. However, adverse effects such as sedation, aversion and depression have limited their clinical development. Recently, salvinorin A (Sal A), an active component of the plant Salvia divinorum was shown to be a potent and selective KOPr agonist. Sal A has a short duration...
PLoS One
2011
Marina M Bellet, Marquis P Vawter, Blynn G. Bunney et al.
Major mood disorders have been linked to abnormalities in circadian rhythms, leading to disturbances in sleep, mood, temperature, and hormonal levels. We provide evidence that ketamine, a drug with rapid antidepressant effects, influences the function of the circadian molecular machinery. Ketamine modulates CLOCK:BMAL1-mediated transcriptional activation when these regulators are ectopically...
Tidsskrift for Den norske legeforening
2011
Arne Helland
ANMELDELSERLSDs basale farmakologi.Her har den i seg stoff til å være et referanseverk for farmakologer og toksikologer.Dette er sentralt fagstoff om kjemisk struktur, metabolitter, reseptorvirkning, interaksjoner og dyreforsøk på toksisitet.Her er boken omfattende nok og relativt nyansert, selv om den refererende stilen, uten synteser, gjør teksten tung å lese noen ganger.Dette utgjør nesten...
Cognitive Neuroscience
2011
David A. Leopold
The explicit link between awareness and sociality put forward in the accompanying article opens new doors to thinking about the evolutionary origins of consciousness. Human subjective experience undoubtedly has some features that are species-specific and others that are shared over a broad phylogenetic base. The authors' proposal that consciousness depends on high-level neural circuits evolved...