PLoS One
June 15, 2016
Andrea E. Steuer, Corina Schmidhauser, Eva H Tingelhoff et al.
18 citations
3,4-methylenedioxymethamphetamine (MDMA; ecstasy) metabolism is known to be stereoselective, with preference for S-stereoisomers. Its major metabolic step involves CYP2D6-catalyzed demethylenation to 3,4-dihydroxymethamphetamine (DHMA), followed by methylation and conjugation. Alterations in CYP2D6 genotype and/or phenotype have been associated with higher toxicity. Therefore, the impact of...
PLoS One
June 14, 2016
Heidi Koldsø, Henriette Elisabeth Autzen, Julie Grouleff et al.
The competitive inhibitor cocaine and the non-competitive inhibitor ibogaine induce different conformational states of the human serotonin transporter. It has been shown from accessibility experiments that cocaine mainly induces an outward-facing conformation, while the non-competitive inhibitor ibogaine, and its active metabolite noribogaine, have been proposed to induce an inward-facing...
Journal of Emergency Medicine Case Reports
June 14, 2016
Çağdaş Yıldırım, Gülhan Kurtoğlu Çelik, Gullu Ercan Haydar et al.
6 citations
Introduction: The emergency department is the most common site of presentation for patients suffering from acute mushroom poisoning; therefore, emergency physicians should be familiar with it. We present a case of mushroom poisoning that was initially misdiagnosed as a cerebrovascular event.Case Report: A 59-year-old male patient was referred to our emergency service from another hospital with...
PLoS Genetics
June 14, 2016
Rachel Bachner-Melman, Christian Dina, Ada H Zohar et al.
Dancing, which is integrally related to music, likely has its origins close to the birth of Homo sapiens, and throughout our history, dancing has been universally practiced in all societies. We hypothesized that there are differences among individuals in aptitude, propensity, and need for dancing that may partially be based on differences in common genetic polymorphisms. Identifying such...
PLoS One
June 11, 2016
Sébastien Ballesta, Gilles Reymond, Matthieu Pozzobon et al.
7 citations
3,4-methylenedioxy-N-methyl amphetamine (MDMA) is one of the few known molecules to increase human and rodent prosocial behaviors. However, this effect has never been assessed on the social behavior of non-human primates. In our study, we subcutaneously injected three different doses of MDMA (1.0, 1.5 or 2.0mg/kg) to a group of three, socially housed, young male long-tailed macaques. More than...
PLoS One
June 10, 2016
Katharine N Thakkar, Heathman S Nichols, Lindsey G Mcintosh et al.
273 citations
A weakened sense of self may contribute to psychotic experiences. Body ownership, one component of self-awareness, can be studied with the rubber hand illusion (RHI). Watching a rubber hand being stroked while one's unseen hand is stroked synchronously can lead to a sense of ownership over the rubber hand, a shift in perceived position of the real hand, and a limb-specific drop in stimulated...
Drug Testing and Analysis
June 6, 2016
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal et al.
62 citations
Lysergic N,N-diethylamide (LSD) is perhaps one of the most intriguing psychoactive substances known and numerous analogs have been explored to a varying extent in previous decades. In 2013, N6-allyl-6-norlysergic acid diethylamide (AL-LAD) and (2’S,4’S)-lysergic acid 2,4-dimethylazetidide (LSZ) have appeared on the ‘research chemicals’ / new psychoactive substances (NPS) market in both powdered...
Frontiers in Psychology
June 5, 2016
Jason Samaha, John J. Barrett, Andrew D. Sheldon et al.
124 citations
Visual awareness is hypothesized to be intimately related to visual working memory (WM), such that information present in WM is thought to have necessarily been represented consciously. Recent work has challenged this longstanding view by demonstrating that visual stimuli rated by observers as unseen can nevertheless be maintained over a delay period. These experiments have been criticized,...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
June 3, 2016
Andrea Ossato, Isabella Canazza, Claudio Trapella et al.
JWH-250 and JWH-073 are two synthetic cannabinoid agonists with nanomolar affinity at CB1 and CB2 receptors. They are illegally marketed within "herbal blend" for theirs psychoactive effects greater than those produced by Cannabis. Recently, we analyzed an "herbal" preparation containing a mixture of both JWH-250 and JWH-073. The present study was aimed at investigating the in vitro and in vivo...
Oxford Handbooks Online
June 2, 2016
Christian Coseru
In challenging the physicalist conception of consciousness advanced by Cārvāka materialists such as Bṛhaspati, the Buddhist philosopher Śāntarakṣita addresses a series of key issues about the nature of causality and the basis of cognition. This chapter considers whether causal accounts of generation for material bodies are adequate in explaining how conscious awareness comes to have the...