Clinical Pharmacokinetics
March 28, 2017
Randall Brown, Christopher R. Nicholas, Nicholas V. Cozzi et al.
189 citations
IntroductionPsilocybin is a psychedelic tryptamine that has shown promise in recent clinical trials for the treatment of depression and substance use disorders. This open-label study of the pharmacokinetics of psilocybin was performed to describe the pharmacokinetics and safety profile of psilocybin in sequential, escalating oral doses of 0.3, 0.45, and 0.6 mg/kg in 12 healthy...
March 25, 2017
John Z. Ma
EEG signals are records of nonlinear solitary waves in human brains. The waves have several types (e.g., a, b, g, q, d) in response to different levels of consciousness. They are classified into two groups: Group-1 consists of complex storm-like waves (a, b, and g); Group-2 is composed of simple quasilinear waves (q and d). In order to elucidate the mechanism of EEG wave formation and...
Frontiers in Psychology
March 21, 2017
Jakub Jonkisz, Michał Wierzchoń, Marek Binder
32 citations
Both the multidimensional phenomenon and the polysemous notion of consciousness continue to prove resistant to consistent measurement and unambiguous definition. This is hardly surprising, given that there is no agreement even as regards the most fundamental issues they involve. One of the basic disagreements present in the continuing debate about consciousness pertains to its gradational...
Journal of Neuroscience
March 15, 2017
Mitchell D Oakes, Wen Jing Law, Tobias Clark et al.
Cannabis sativa, or marijuana, a popular recreational drug, alters sensory perception and exerts a range of potential medicinal benefits. The present study demonstrates that the endogenous cannabinoid receptor agonists 2-arachidonoylglycerol (2-AG) and anandamide (AEA) activate a canonical cannabinoid receptor in Caenorhabditis elegans and also modulate monoaminergic signaling at multiple...
Journal of Medicinal Chemistry
March 15, 2017
Richard A Glennon
The phenylalkylamine, particularly the phenylethylamine, moiety is a common structural feature found embedded in many clinically approved agents. Greater still is its occurrence in drugs of abuse. The simplest phenylethylamine, 2-phenylethylamine itself, is without significant central action when administered at moderate doses, but fairly simple structural modifications profoundly impact its...
Fermentation Technology
March 13, 2017
Feridun Gürlek, Eyyüp Taådemir, T. Teker
1 citation
Nowadays, narcotic and enjoyable substances threaten especially adolescents and young people. These substances are fairly common and various. This makes them easier to access. Their use is also closely associated with low socio-economic and socio-cultural conditions. It has been known psychoactive and hallucinogenic effects of Salvia divinorum for many years. It is abused for this purpose. In...
Pain Medicine
March 10, 2017
Mala C. Mandyam, Neera K. Ahuja
10 citations
Dear Editor, Complex regional pain syndrome (CRPS) describes a disease of localized chronic pain that often occurs after preceding trauma, is out of proportion to its expected course, and includes other symptoms such as hair loss and allodynia [1]. There are no known psychologic or personality factors associated with its development [2]. Therapy is multimodal, and pharmacologic treatments...
Frontiers in Psychology
March 3, 2017
Markus Kiefer, Thomas Kammer
One aspect of consciousness phenomena, the temporal emergence of visual awareness, has been subject of a controversial debate. How can visual awareness, that is the experiential quality of visual stimuli, be characterized best? Is there a sharp discontinuous or dichotomous transition between unaware and fully aware states, or does awareness emerge gradually encompassing intermediate states?...
Schizophrenia Bulletin
March 1, 2017
Robin Murray
Overall Abstract: Dr Marta Di Forti Cannabis use across Europe and its interaction with the polygenic risk score for schizophrenia. Dr Di Forti examined the pattern of cannabis use across 16 European sites as part of the EU-GEI study. She will show striking differences in incidence of psychosis (high in North and low in South), and how differences in pattern of cannabis use result in...
Acta pharmacologica Sinica
March 2017
De-Jie Chen, Ming Gao, Fen-Fei Gao et al.
Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of molecules, some with psychoactive effects. At least 4% of the world's adult population uses cannabis annually, making it one of the most frequently used illicit drugs in the world. The psychoactive effects of cannabis are mediated primarily through cannabinoid receptor (CBR) subtypes. The prevailing...