Psychopharmacology
July 19, 2016
Kim P. C. Kuypers, Jordi Riba, Mario de la Fuente Revenga et al.
204 citations
INTRODUCTION: Ayahuasca is a South American psychotropic plant tea traditionally used in Amazonian shamanism. The tea contains the psychedelic 5-HT2A receptor agonist N,N-dimethyltryptamine (DMT), plus β-carboline alkaloids with monoamine oxidase-inhibiting properties. Increasing evidence from anecdotal reports and open-label studies indicates that ayahuasca may have therapeutic effects in...
Nature Communications
July 18, 2016
Erez Simony, Christopher J Honey, Janice Chen et al.
689 citations
Does the default mode network (DMN) reconfigure to encode information about the changing environment? This question has proven difficult, because patterns of functional connectivity reflect a mixture of stimulus-induced neural processes, intrinsic neural processes and non-neuronal noise. Here we introduce inter-subject functional correlation (ISFC), which isolates stimulus-dependent...
Journal of Visualized Experiments
July 9, 2016
Terrell Holloway, José L. Moreno, Javier González-Maeso
The heteromeric receptor complex between 5-HT2A and mGlu2 has been implicated in some of the behavioral phenotypes in mouse models of psychosis(1,2). Consequently, investigation of structural details of the interaction between 5-HT2A and mGlu2 affecting schizophrenia-related behaviors represents a powerful translational tool. As previously shown, the head-twitch response (HTR) in mice is...
Tikkun
July 6, 2016
Phil Wolfson
3 citations
Research Article| January 01 2011 Psychedelics, Spirituality, and Transformation Phil Wolfson Phil Wolfson Author InformationPhil Wolfson, MD, is a practicing psychiatrist/psychotherapist in the Bay Area. He is the author of the forthcoming Noe—A Father/Son Song of Love, Life, Sickness and Death. Search for other works by this author on: This Site Google Tikkun (2011) 26 (1): 10–88....
Addictive Disorders & Their Treatment
July 4, 2016
Fares Alharbi, Nady el‐Guebaly
9 citations
Background: The recent escalation of cannabis and amphetamine-type stimulant use throughout the world and its association with psychotic symptoms in users has fuelled special concerns. Objective: This review will focus on cannabis and amphetamine-type stimulant because of their high prevalence and will try to differentiate and compare their associated psychotic features. Method: A systematic...
Frontiers in Psychology
July 4, 2016
Jennifer Streiffer Mascaro, Alana eDarcher, Lobsang Tenzin Negi et al.
Although kindness-based contemplative practices are increasingly employed by clinicians and cognitive researchers to enhance prosocial emotions, social cognitive skills, and well-being, and as a tool to understand the basic workings of the social mind, we lack a coherent theoretical model with which to test the mechanisms by which kindness-based meditation may alter the brain and body. Here we...
Neuropsychopharmacology
July 2016
Margaret Haney, Robert J Malcolm, Shanna Babalonis et al.
Cannabidiol (CBD), a constituent of cannabis with few psychoactive effects, has been reported in some studies to attenuate certain aspects of Δ(9)-tetrahydrocannabinol (THC) intoxication. However, most studies have tested only one dose of CBD in combination with one dose of oral THC, making it difficult to assess the nature of this interaction. Further, the effect of oral CBD on smoked cannabis...
Journal of Pharmacology and Experimental Therapeutics
July 2016
J M Witkin, J A Monn, D D Schoepp et al.
Ketamine is a rapidly acting antidepressant in patients with treatment-resistant depression (TRD). Although the mechanisms underlying these effects are not fully established, inquiry to date has focused on the triggering of synaptogenesis transduction pathways via glutamatergic mechanisms. Preclinical data suggest that blockade of metabotropic glutamate (mGlu2/3) receptors shares many...
Drug and Alcohol Dependence
July 1, 2016
D P Katz, Jack DeRuiter, D Bhattacharya et al.
Designer drugs are synthetic structural analogues/congeners of controlled substances with slightly modified chemical structures intended to mimic the pharmacological effects of known drugs of abuse so as to evade drug classification. Benzylpiperazine (BZP), a piperazine derivative, elevates synaptic dopamine and serotonin levels producing stimulatory and hallucinogenic effects, respectively,...
Experimental Agriculture
July 1, 2016
Getachew Sime, Jens B. Aune
SUMMARY: Intensification of maize production is imperative to improve food security for the rising population in the central rift valley (CRV) of Ethiopia, whose livelihood is principally based on rainfed maize that operates under shrinking landholding and high seasonal rainfall variability. This study examined different levels of intensification options in maize production by sequentially...