ILAR Journal
2011
Divya Ramesh, Joel E Schlosburg, Jason M Wiebelhaus et al.
Marijuana (Cannabis sativa) is the most commonly used illicit drug worldwide as well as in the Unites States. Prolonged use of marijuana or repeated administration of its primary psychoactive constituent, Δ9-tetrahydrocannabinol (THC), can lead to physical dependence in humans and laboratory animals. The changes that occur with repeated cannabis use include alterations in behavioral,...
Indian Journal of Psychiatry
January 2011
Shubhangi R Parkar, Seethalakshmi Ramanathan, Narendra Nair et al.
Cannabis has been associated with transient psychotic states; however, the causal relationship between cannabis and schizophrenia continues to remain a matter of debate. Epidemiological and some biological studies hint at cannabis being an independent risk factor for schizophrenia; this has not been definitively proved. We aimed to understand the patterns of glucose uptake in important brain...
ILAR Journal
2011
Keith A Trujillo, Monique L. Smith, Brian Sullivan et al.
Ketamine was developed in the early 1960s as an anesthetic and has been used for medical and veterinary procedures since then. Its unique profile of effects has led to its use at subanesthetic doses for a variety of other purposes: it is an effective analgesic and can prevent certain types of pathological pain; it produces schizophrenia-like effects and so is used in both clinical studies and...
PhilPapers (PhilPapers Foundation)
2011
Esteban Céspedes
One of the principal presuppositions in the extended mind account of Clark and Chalmers establishes that extended and non-extended cognitive systems have somehow the same structure and that the distinctions between them can only be superficial. In contrast, this work presents some arguments for the idea that it is possible to find fundamental differences between both, mainly on the basis that a...
Journal of Psychoactive Drugs
2011
Donald R Wesson
22 citations
The 1960s were a time of social upheaval, wars, vibrant creativity and missed opportunity. Mainstream culture and a psychedelic drug-using counterculture shared a belief in "better living through chemistry'," but they disagreed about the particular chemistry. The Vietnam war and the cold war with the Soviet Union, racial discrimination, and gender roles fueled political activism. "Yes we can"...
Addiction
October 2010
Judson A. Brewer, Sarah Bowen, Joseph T Smith et al.
Both depression and substance use disorders represent major global public health concerns and are often co-occurring. Although there are ongoing discoveries regarding the pathophysiology and treatment of each condition, common mechanisms and effective treatments for co-occurring depression and substance abuse remain elusive. Mindfulness training has been shown recently to benefit both...
The Journal of Alternative and Complementary Medicine
August 1, 2010
Introducing qigong meditation into residential addiction treatment: a pilot study where gender makes a difference.
Dtsch Arztebl Int
July 30, 2010
Dextromethorphan withdrawal and dependence syndrome.
Addiction Biology
July 2010
Saturnino Spiga, Alessandra Lintas, Michele Migliore et al.
Cannabinoid withdrawal produces a hypofunction of mesencephalic dopamine neurons that impinge upon medium spiny neurons (MSN) of the forebrain. After chronic treatment with two structurally different cannabinoid agonists, Delta(9)-tetrahydrocannabinol and CP55 940 (CP) rats were withdrawn spontaneously and pharmacologically with the CB1 antagonist SR141716A (SR). In these two conditions,...
Drug and Alcohol Dependence
June 17, 2010
Josep María Fábregas, Débora González, Sabela Fondevila et al.
228 citations
Ayahuasca is a psychoactive beverage used for magico-religious purposes in the Amazon. Recently, Brazilian syncretic churches have helped spread the ritual use of ayahuasca abroad. This trend has raised concerns that regular use of this N,N-dimethyltryptamine-containing tea may lead to the medical and psychosocial problems typically associated with drugs of abuse. Here we assess potential drug...