PLoS Computational Biology
July 1, 2022
Michelle J. Redinbaugh, Mohsen Afrasiabi, Jessica M. Phillips et al.
Anesthetic manipulations provide much-needed causal evidence for neural correlates of consciousness, but non-specific drug effects complicate their interpretation. Evidence suggests that thalamic deep brain stimulation (DBS) can either increase or decrease consciousness, depending on the stimulation target and parameters. The putative role of the central lateral thalamus (CL) in consciousness...
bioRxiv Preprint Server
July 27, 2021
Michelle J. Redinbaugh, Mohsen Afrasiabi, Jessica M. Phillips et al.
preprint
Anesthetic manipulations provide much-needed causal evidence for neural correlates of consciousness, but non-specific drug effects complicate their interpretation. Evidence suggests that thalamic deep brain stimulation (DBS) can either increase or decrease consciousness, depending on the stimulation target and parameters. The putative role of the central lateral thalamus (CL) in consciousness...
Cell Systems
March 12, 2021
Mohsen Afrasiabi, Michelle J. Redinbaugh, Jessica M. Phillips et al.
SUMMARY: The neural substrates of consciousness remain elusive. Competing theories that attempt to explain consciousness disagree on the contribution of frontal versus posterior cortex and omit subcortical influences. This lack of understanding impedes the ability to monitor consciousness, which can lead to adverse clinical consequences. To test substrates and measures of consciousness, we...
bioRxiv Preprint Server
April 7, 2020
Mohsen Afrasiabi, Michelle J. Redinbaugh, Jessica M. Phillips et al.
preprint
Major theories of consciousness disagree on the key neural substrates. In Global Neuronal Workspace Theory and Higher-order Theories, consciousness depends on frontal cortex, whereas Integrated Information Theory and Recurrent Processing Theory highlight posterior contributions. Most theories omit subcortical influences. To test these theories, we performed simultaneous frontal, parietal,...
Neuron
January 22, 2020
Michelle J. Redinbaugh, Jessica M. Phillips, Niranjan A. Kambi et al.
SUMMARY: Functional MRI and electrophysiology studies suggest consciousness depends on large-scale thalamocortical and corticocortical interactions. However, it is unclear how neurons in different cortical layers and circuits contribute. We simultaneously recorded from central lateral thalamus (CL) and across layers of frontoparietal cortex in awake, sleeping and anesthetized macaques. We found...
bioRxiv Preprint Server
October 1, 2019
Michelle J. Redinbaugh, Jessica M. Phillips, Niranjan A. Kambi et al.
preprint
Consciousness is the capacity to experience one’s environment and internal states. The minimal mechanisms sufficient to produce this experience, the neural correlates of consciousness (NCC), are thought to involve thalamocortical and intracortical interactions, but the key operations and circuit paths are unclear. We simultaneously recorded neural activity in central thalamus and across layers...