Medicine is taught as a science, but in reality, as with other areas that undergo much public scrutiny, it is often more of an art than a science. Particularly when dealing with controversial areas, physicians often attempt to employ the "standard of care" as a guide to practising medicine, and to protect themselves. However, the standard of care itself is often a reactive and temporary...
Psilocybin produces an altered state of consciousness in humans and is associated with complex spatiotemporal changes in cortical networks. Given the emphasis on rodent models for mechanistic studies, there is a need for characterization of the effect of psilocybin on cortex-wide network dynamics. Previous electroencephalographic studies of psychedelics in rodents have primarily used sparse...
Background: Psilocybin has shown promise in therapeutic applications for mental disorders. Understanding the pharmacokinetics of psilocybin and its active metabolite psilocin is crucial for optimizing its clinical use and minimizing adverse effects. Methods: This systematic review involved a comprehensive search across MEDLINE, APA PsycINFO, and Embase databases, from inception to December...
There is great public and clinical interest in the use of psychedelics for therapeutic purposes. However, there has been little national study of psychedelic use in the U.S. veteran population. This study used quantitative and qualitative data from a nationally representative survey of 1,031 low-income U.S. veterans who participated in the National Veteran Homeless and Other Poverty Experiences...
Quality in SportMarch 21, 2025Kacper Rusiński, Filip Klimas, Dorota Zatłoka-Mazur et al.1 citation
Cannabis is one of the most widely used psychoactive substances globally. In several countries, including Canada, the Netherlands, certain U.S. states, and Australia, its possession is legal. With its growing popularity in recent years, the impact of cannabis on mental health has become a focal point of numerous scientific studies. The aim of this review was to summarize the current...
Objective: To narratively review currently available antidepressants and future potential antidepressants as monotherapy for the treatment of depressive disorders. Methods: Selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), dopamine reuptake inhibitor (bupropion), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs) were...
The aim of the study is to evaluate the effects of basic yoga and meditation techniques on the anxiety and perceived stress levels of midwifery students. This study is a randomized controlled experimental study. The study was conducted with students of the Midwifery Department of a public university in Turkey. Data were collected using the “Student Diagnosis and Follow-up Form”, “Beck Anxiety...
This study draws attention to, and provides a description of, a previously unmapped and emerging self-medication phenomenon occurring in Aotearoa New Zealand where psychedelic substances are being used in the absence of clinical supervision to address a wide range of health and wellbeing issues, partly in response to unmet mental health needs. We interviewed 34 individuals who had...
There is currently a resurgence in exploring the utility of classical psychedelics to treat depression, addiction, anxiety disorders, cluster headaches, and many other neuropsychiatric disorders. A biological target of these compounds, and a hypothesized target for their therapeutic actions, is the 5-HT2A serotonin receptor. Here, we present 7 cryo-EM structures covering all major compound...
Abstract Objectives With raising rates of mental health problems, mind–body interventions are increasingly being integrated in schools to support children and adolescents' mental health and well‐being. The aim of this study was to explore young adolescents' experiences of yoga and mindfulness and the acceptability of delivery within the school curriculum in an area of high deprivation. Design...