bioRxiv : the preprint server for biology
May 23, 2025
Amanda M. White, Adele D. Bauer, Serge Faumont et al.
preprint
Psychedelics show promise in treating depression, PTSD, and substance use disorder, prompting research into their mechanisms of action. Most studies use rodent models, but genetic tools can be challenging to apply. Invertebrate models, like C. elegans , offer a cost-effective alternative with short generation times and genetic tractability. This study examined the worm's response to the...
British Journal of Pharmacology
May 23, 2025
Trevor Sharp, Aurelija Ippolito
8 citations
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s. However, these drugs are now experiencing a renaissance in the field of psychiatry based on increasing evidence that...
L'Encephale
May 23, 2025
Maroussia Dumenil, Gabriel Cordova, Wissam El-Hage
1 citation
Current antidepressants have shown certain limitations in the treatment of unipolar depression. Their long onset of action, interactions, and side effects are obstacles to achieving lasting remission of this prevalent, often chronic or recurrent, pathology. Faced with this clinical necessity, research efforts have intensified in recent years around psychedelic drugs, with a particular focus on...
Contemporary School Psychology
May 21, 2025
Rachel A. Razza, Qingyang Liu, Ruohan Feng et al.
1 citation
Abstract School-based mindfulness programs help students manage stress and promote well-being. These programs largely reflect a developmental psychological mindfulness framework that posits that intrinsic states of mindfulness and basic compassion can be cultivated into traits through socialization and training. Yet less is known about how program effects vary depending on individual and...
Current Psychology
May 21, 2025
Gemma Perry, Yanan Sun, Vince Polito et al.
Chanting is a universal practice with deep ethnocultural roots. More recently, chanting has become popular on online platforms and meditation apps which have extended chanting practices beyond their original cultural, sacred, and healing traditions. The aim of the current study was to determine if online chanting meditation promotes altered states of consciousness and psychosocial benefits when...
Biopharmaceutics & drug disposition
May 21, 2025
Xiang Zheng, Haiyan Chen, Dan Lin et al.
2 citations
Most cancer patients experience severe pain, and apatinib, a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, demonstrates therapeutic efficacy against gastric cancer. Ketamine, a psychotropic drug used for cancer pain relief, exhibits potential in inhibiting gastric cancer progression but is associated with dose-dependent adverse effects including neurological toxicity and...
Cell Reports
May 21, 2025
Lace M Riggs, Sage Aronson, Ta-Chung M. Mou et al.
2 citations
An acute increase in excitatory synaptic transmission contributes to the rapid antidepressant actions of neuroplastogens, including ketamine and its bioactive metabolite, (2R,6R)-hydroxynorketamine (HNK). It is hypothesized that drug-induced metaplastic changes in synaptic strength account for therapeutically relevant behavioral adaptations in vivo. Using the plasticity-deficient Wistar Kyoto...
bioRxiv Preprint Server
May 20, 2025
Vasil Kolev, Peter Malinowski, Antonino Raffone et al.
preprint
Objectives The main objective of the present study was to explore the effects of different types of meditation on the neurophysiologic mechanisms of pain processing.
Physiology & Behavior
May 20, 2025
Kaspar McCoy, Felicia Reed, Kyna‐anne Conn et al.
4 citations
Psilocybin, a serotonergic psychedelic, has emerged as a promising treatment for a range of mental health conditions, including anorexia nervosa. Recent insights from animal models and human imaging studies suggest psilocybin enhances cognitive flexibility and modifies reward processing - two core processes disrupted in anorexia nervosa. Both cognitive flexibility and reward processing are...
Mindfulness
May 17, 2025
Michel Sabé, Chaomei Chen, Davy Vancampfort et al.
7 citations
Abstract Objectives We conducted a scientometric analysis on mind–body interventions to assess themes and trends in recent decades, providing insights for prospective research directions. Our systematic search, completed on 1 November, 2023, encompassed the Web of Science Core Collection and focused on scientific publications related to contemplative practices: Mindfulness, Yoga, Qi-gong,...