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The Missed Conversation August 15, 2025 Bettina Bergo
Abstract This chapter explores Husserl’s innovative conception of immanent time in three parts: retention, now-moments, and protention. It explains his advance relative to Brentano’s conception of time and memory being the result of “productive imagination.” Early on, it demonstrates that sensation, welling up from the body, both accounted for our feeling of temporal flow and depended on that...
Psychiatry Research August 15, 2025 Sipan Haikazian, Roger S McIntyre, Shakila Meshkat et al. 7 citations
Antidepressant effects with sub-anesthetic doses of intravenous ketamine have been previously demonstrated. However, previous studies have primarily evaluated the efficacy of acute treatment protocols, with limited research on maintenance treatment. Moreover, controlled maintenance studies have only included patients with treatment-resistant Major Depressive Disorder (TRD), with no maintenance...
Frontiers in Psychiatry August 15, 2025 Yvonne Bonomo, Amanda F. Norman, Lisa Collins et al. 1 citation
Introduction: Ayahuasca is a psychedelic compound of N, N, Dimethyltryptamine (DMT) and harmala alkaloids used for spiritual and medicinal applications in traditional settings. A range of potential psychotherapeutic mechanisms have been proposed for ayahuasca. These are thought to contribute to improvements in various psychiatric conditions including mood disorders and substance dependence....
Journal of Affective Disorders August 15, 2025 Xinya Hong, Sen Xu, Gaozhong Sun et al. 3 citations
This multicenter, randomized, placebo-controlled, clinical trial was designed to investigate the efficacy and safety of esketamine (ESK) for smoking cessation. The study enrolled a sample of 236 patients diagnosed with lung cancer and major depression disorder (MDD). Treatment included intranasal delivery of ESK or placebo once a week for 8 sessions. The primary outcomes were self-reported and...
Imaging Neuroscience August 14, 2025 Radek Ptak, Naz Doganci, Emilie Marti et al.
Abstract Mental transformations, such as mental rotation, rely on motor representations and engage neural processes similarly to physical actions. Neuroimaging studies reveal that mental rotation activates the occipito-parietal cortex and motor-related areas, with differences based on whether stimuli are bodily or non-bodily. These findings emphasize the role of frontoparietal networks in...
Clinical pharmacology and therapy August 14, 2025 R. McIntyre, Gerard Sanacora, David P. Walling et al.
Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response to ongoing antidepressant monotherapy....
Brazilian Journal of Implantology and Health Sciences August 14, 2025 A. Silva, Érika Barros Teixeira da Cruz, Samuel Cândido Freres et al.
O transtorno de estresse pós-traumático (TEPT) é uma condição psiquiátrica caracterizada por sintomas persistentes após vivência de eventos traumáticos, incluindo revivescências, hipervigilância e esquiva. Estudos recentes têm apontado o uso de psicodélicos, como MDMA e psilocibina, como potenciais coadjuvantes no tratamento, devido à sua capacidade de promover neuroplasticidade e facilitar a...
Psychiatry and Clinical Psychopharmacology August 14, 2025 Nadav Liam Modlin, Jessica L Maples-Keller, Maria Sarang et al.
Background: Current trauma treatment options often fail to meet patients' needs. Despite the availability of established interventions, many trauma treatments fail to adequately meet patients' needs. In parallel, there has been renewed scientific and public interest in the therapeutic potential of psychedelics and related compounds, accompanied by increasing unsupervised use. This underscores...
Journal of Psychedelic Studies August 13, 2025 Michael J. Winkelman
This paper examines possible future evolution through knowledge of how past human evolution constrains possibilities for the future. Uniquely human evolution-brain, ultrasociality, and cultural niche development-are examined to see what these suggest about future adaptations. Rapid brain evolution involves neuroplasticity, a re-use and rewiring of neural networks. Psychedelics are extraordinary...
Behavioral Sciences August 12, 2025 Veronika Alekseeva, Anna Ciaunica
From the moment we are born, and even before, in the womb, and until our last breath, our bodies move all the time. Adaptive behaviors necessarily depend not only on the successful integration of multisensory bodily signals but also on how we move our bodies in the world. This paper considers the notion of embodied selfhood through the perspective of dynamic and rhymical coupling between bodily...