Behavioral and Brain Sciences
October 2, 2026
Yi-Sheng Wong
Haueis and Colaço distinguish evaluative and generative roles for metabolic considerations in cognitive modeling. I extend this framework to the default mode network, arguing that this network's elevated aerobic glycolysis constitutes a metabolic constraint on spontaneous thought. This constraint shapes the richness of spontaneous thought across varying task demands and predicts load-dependent...
bioRxiv (Cold Spring Harbor Laboratory)
October 2, 2026
Madison J Oulton, Gracious D. S. Kasheke, Kelly A. Meaney et al.
preprint
We have examined how ibogaine may enhance synaptic plasticity and neural repair. Extracellular efflux analysis showed that ibogaine (3, 10 or 30 μM) produced a rapid (<5 minutes) and concentration-dependent suppression of mitochondrial function and glycolysis in mouse cortical neurons. Cell-based imaging demonstrated this metabolic inhibition was preceded by an elevation of the mitochondrial...
International Journal of Homoeopathic Sciences
October 1, 2026
Diyaana Z Crri, R Sakthi, R Samaran
Hallucinations are disturbances of perception in which a person experiences vivid sensory phenomena even though there is no corresponding external stimulus. They can involve different sensory modalities, including hearing voices or sounds, seeing people or objects, perceiving unusual smells or tastes, or experiencing sensations of touch or bodily movement. Although hallucinations are frequently...
Medical Journal of Dr. D.Y. Patil Vidyapeeth
October 1, 2026
Nikhar Satyapal, Parisha Kelkar, Abhimanyu Sinha et al.
A BSTRACT Cannabis is the most widely used illicit psychoactive substance worldwide. While cannabis-related psychosis is well documented, cannabis-associated mania is a relatively under-recognized clinical entity that poses diagnostic and therapeutic challenges. We describe three young adult males who presented with first-episode mania following a recent escalation of cannabis consumption. All...
Brain and Environment
October 1, 2026
Sophie Schuller, Annique Laurens Janse, Lisanne Bergefurt et al.
Despite extensive research on the influence of office environments on occupant health, the sensory mechanisms through which workplaces influence psychophysiological stress remain poorly understood, particularly beyond visual and acoustic factors. This pilot study examined how olfactory and tactile qualities of office environments influence psychophysiological stress using a...
Brain and Behavior
October 2026
Ruiqi Rachel Luo, David J. Berlowitz, Alexander Bryson et al.
Psilocybin is a naturally occurring classic psychedelic associated with widespread changes in brain function and promising therapeutic outcomes in several neuropsychiatric disorders. Complementing these findings, qualitative studies following psilocybin administration have revealed diverse and highly individual effects across multiple domains of subjective experience. However, little is known...
Journal of Neuroendocrinology
October 1, 2026
Cristian Ferreira Corona, Felipe Alves Alencar Lima, Jessica Sabrina Canedo da Silva Sumensse et al.
Abstract Human binge eating disorder is characterized by recurrent episodes of excessive food consumption accompanied by loss of control and is strongly associated with alterations in reward processing and emotional regulation. Ayahuasca, a psychoactive botanical preparation traditionally used in Amazonian medicine, has been shown to modulate serotonergic signaling and reward‐related behaviors...
Pain Management
October 1, 2026
Steven Paul Cohen, Roman Smolynets, Jordan Wood et al.
BACKGROUND: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are conditions that share common mechanisms and are highly co-prevalent with each other and chronic pain. This pragmatic study will compare ketamine infusions to stellate ganglion blocks (SGB), their combination, and a placebo-sham-controlled arm. METHODS: A double-blind study conducted at 3 U.S. and Ukrainian...
Psychedelics
October 1, 2026
Diego Borbón
In April 2025, New Mexico enacted the Medical Psilocybin Act, establishing the first legislated statewide medical psilocybin program and becoming the third state to authorize supervised psilocybin use. The Act directs the New Mexico Department of Health to build a regulated system where licensed clinicians provide psilocybin to qualified patients in approved settings for treatment-resistant...
Psychedelics
October 1, 2026
Benjamin R. Lewis, Eric L Garland, Zach Schwartz et al.
Background Psychedelic-assisted psychotherapy (PAP) has demonstrated great promise for a variety of mental health problems. Many clinicians and researchers who are engaged in providing PAP report personal experiences with psychedelics; these experiences are often positive. Still, there are ongoing questions regarding the relevance of therapists personal experience with psychedelic drugs for the...