Abstract Background and Purpose Given the increase in recreational psychedelic use and ongoing efforts to explore psychedelics as therapeutic agents for mental health disorders, there is an urgent need to understand the effect of psychedelics such as psilocybin and N,N-dimethyltryptamine (DMT) on sleep-wake states, which share a bidirectional relationship with mental health. Here, we...
ACS Chemical NeuroscienceOctober 13, 2025Rajiv Agrawal, Daniel J. Gillie, Alison E. Mungenast et al.8 citations
Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid and enduring therapeutic effects of psychedelics and the dissociative anesthetic ketamine. However, safety concerns related to hallucinogenic/dissociative properties have limited the addressable...
Abstract Nanoformulation is often used to improve the solubility and uptake of bioactives; however, it also protects sensitive bioactives from chemical decomposition. A class of biocompatible emulsifiers created by conjugating hemp protein with green tea polyphenols is reported. A simple pH‐assisted coupling protocol is employed to synthesize covalent and non‐covalent conjugates, which are then...
Ayahuasca is a traditional hallucinogenic concoction utilised by indigenous populations in the Amazon Basin for ages in spiritual and therapeutic rituals. The increasing global popularity is attributed to its alleged medicinal and consciousness-expanding properties. The infusion is primarily composed of two key components: the Banisteriopsis caapi vine and the leaves of Psychotria viridis,...
Psychedelics, such as psilocybin, lysergic acid diethylamide (LSD), ketamine, and N,N-dimethyltryptamine (DMT), have captured the attention of scientists, artists, and seekers alike for their profound ability to alter consciousness and inspire creativity. The concept of "creation" encompasses multiple interpretations-ranging from generating novel ideas to fostering personal transformation. This...
Psychedelics have a profound potential to catalyze psychological transformation and support traditional cultures and ways of life. However, many naturally occurring psychoactive plants and animals are facing threats from climate change, habitat loss and other anthropogenic pressures like overharvesting. In this narrative review we examine the conservation issues pertaining to some of the most...
Brazilian Journal of ScienceSeptember 29, 2025Pinelopi Vlotinou, Konstantinos Christodoulou, Anna Tsiakiri et al.
Classical psychedelics encompass psilocybin, lysergic acid diethylamide (LSD), N, N-dimethyltryptamine (DMT), and mescaline and are psychoactive substances that primarily function as agonists at the serotonin 5-hydroxytryptamine receptors (5-HT). In the immediate term, they modify perception, cognition, emotional state, social processing, and introspection, leading to a subjective mystical...
Brain DisordersSeptember 23, 2025Matthew Halma, R. Levy, Joseph Varón2 citations
Clinicians and researchers are showing increased interest in psychedelic-assisted therapy for patients who don't show improvement from using conventional antidepressants. This updated review integrates recent developments, including data on lesser-studied compounds like DMT and 5-MeO-DMT, findings from large clinical trials, and evolving regulatory landscapes. In treatment-resistant depression,...
Chemistry & BiodiversitySeptember 23, 2025Nathália Andrezza Carvalho de Souza, Pedro Guilherme Sousa de Sá, Tarcísio Cícero de Lima Araújo et al.2 citations
Mimosa tenuiflora (Willd.) Poir., known as "Jurema-preta", is a species of ethnobotanical relevance, used in traditional medicine. The northeastern backland is characterized by climatic variability, which makes it essential to carry out studies that assess the seasonal influence on the chemical profile of native species. The aim of this study was to evaluate the seasonal variation in the...
CureusSeptember 17, 2025Arya Kermanshah, Margo Stapleton, Christine M Mauriello et al.1 citation
Ayahuasca, a brew containing N,N-dimethyltryptamine (DMT) with monoamine oxidase-inhibiting β-carbolines, has expanded from traditional use to global retreats. Reported adverse effects include vomiting, agitation, serotonin toxicity-like syndromes, and cardiovascular events. Rhabdomyolysis has been described with other classic hallucinogens (e.g., lysergic acid diethylamide and psilocybin),...