Psilocybin, psilocin, 5-MeO-DMT, LSD and mescaline are classical hallucinogens whose recreational use has increased over recent decades (Brito-da-Costa et al., 2021; Dinis-Oliveira et al., 2019; Holze et al., 2021; Jiang et al., 2013). However, data on their interactions with cytochrome P450 (CYP450) enzymes remain scarce, despite the potential for clinically relevant drug–drug interactions....
Abstract Introduction Ayahuasca is a psychoactive brew used in Amazonian ceremonies, containing monoamine oxidase inhibitors (MAOIs) from Banisteriopsis caapi and N,N-dimethyltryptamine (DMT) from Psychotria viridis or Diplopterys cabrerana. Its global use has expanded for perceived antidepressant and anti-addictive effects. However, its MAOI content predisposes users to serotonergic toxicity...
Abstract Introduction Psychedelic use and interest in its therapeutic potential are rapidly increasing; yet its relationship with insomnia remains poorly understood. This study aims to estimate differences in insomnia severity by type of psychedelic consumed among a cohort of 18-to-35-year olds. Methods Data are from the Herbal Heart Study - Sleep Ancillary (N=100) cannabis consumers....
Psilocybe mushrooms (psilocybin/psilocin [PSI/PSC]) and ayahuasca (N,N-dimethyltryptamine [DMT]) are hallucinogenic serotonergic agonists. Pregnant and lactating women are frequently omitted from clinical studies; hence minimal developmental/reproductive/neurotoxicity (DART/DNT) and endocrine disruption (ED) data in humans are available. Hallucinogens contaminated with pesticides may have...
Psychedelic drugs are serotonergic hallucinogens that can be divided into two types: naturally occurring (psilocybin, psilocin, and N,N-dimethyltryptamine) and synthetic (LSD, MDMA, 2,5-dimethoxy-4-iodoamphetamine, and ketamine). Psychedelics generally work on 5-hydroxytryptamine receptors and might be useful in cognitive enhancement, brain connectivity, neuroplasticity, and neuronal...
Este artigo apresenta o protocolo experimental e a base teórica atualizada do Experimento do Século, cujo objetivo central é validar empiricamente a Arquitetura Holográfica da Construção da Realidade (AHCR 2.0), modelo que propõe a consciência como variável físico-informacional mensurável no processo de construção da realidade observável.A origem dessa abordagem remonta à publicação do primeiro...
Serotonergic psychedelics such as N,N-dimethyltryptamine (DMT) and 4-phosphoryloxy-N,N-dimethyltryptamine (psilocybin) show therapeutic promise for psychiatric and neurodegenerative disorders but may be limited by liabilities from serotonin (5-HT)-2A mediated psychoactive effects and potential cardiotoxicity via 5-HT2B activation. To address these limitations, we designed and synthesized...
We propose a three-phase experimental protocol testing whether the radical pair mechanism (RPM) operates during N,N-dimethyltryptamine (DMT)-induced psychedelicstates at the 5-HT2A receptor. Position-specific isotopic substitution of the ligand (13C at C3a, 15N on indole nitrogen) modifies nuclear spin content without altering molecular geometry, receptor affinity, or metabolic...
Importance: Psychedelic drugs possess acute psychoactive effects that can compromise blinding integrity in randomized clinical trials (RCTs). Functional unblinding, when participants or raters correctly identify treatment allocation based on subjective effects, may bias outcomes through expectancy effects, challenging the validity of efficacy estimates and regulatory acceptance. Objective: To...
5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine) has been preliminarily reported to exhibit short-term hallucinogenic effects on humans. However, the connection between its toxic mechanism and behavioral changes remains unexplored. Therefore, this study used zebrafish as the research subject to investigate the metabolic characteristics of 5-MeO-DiPT and its perturbation effects on the metabolic...