Chemistry & Biodiversity
September 23, 2025
Nathália Andrezza Carvalho de Souza, Pedro Guilherme Sousa de Sá, Tarcísio Cícero de Lima Araújo et al.
2 citations
Mimosa tenuiflora (Willd.) Poir., known as "Jurema-preta", is a species of ethnobotanical relevance, used in traditional medicine. The northeastern backland is characterized by climatic variability, which makes it essential to carry out studies that assess the seasonal influence on the chemical profile of native species. The aim of this study was to evaluate the seasonal variation in the...
Chemistry & Biodiversity
September 26, 2022
Albert Katchborian‐neto, Mário F. C. Santos, Diego Fernandes Vilas Boas et al.
9 citations
Abstract Ayahuasca is a psychoactive and psychedelic decoct composed mainly of Banisteriopsis caapi and Psychotria viridis plant species. The beverage is rich in alkaloids and it is ritualistically used by several indigenous communities of South America as a natural medicine. There are also reports in the literature indicating the prophylaxis potential of Ayahuasca alkaloids against internal...
Chemistry & Biodiversity
May 1, 2020
Felix Krengel, Jonathan Dickinson, Christopher Jenks et al.
7 citations
In continuation of our efforts to provide quantitative information on antiaddictive ibogan type alkaloid-producing Tabernaemontana species, we used gas chromatography-mass spectrometry (GC/MS) to compare the alkaloid profiles of the barks and/or leaves of one Mexican and one African species - T. arborea and T. crassa, respectively, with the primary sources of commercially available...
Chemistry & Biodiversity
July 1, 2019
Felix Krengel, Marco V Mijangos, Marisol Reyes-Lezama et al.
17 citations
Several species from the Apocynaceae family, such as Tabernanthe iboga, Voacanga africana, and many Tabernaemontana species, produce ibogan type alkaloids, some of which present antiaddictive properties. In this study, we used gas chromatography/mass spectrometry (GC/MS) to examine the efficiency of methanol, acetone, ethyl acetate, dichloromethane, chloroform, and hydrochloric acid in...
Chemistry & Biodiversity
April 1, 2019
Felix Krengel, Quentin Chevalier, Jonathan Dickinson et al.
10 citations
Ibogaine and other ibogan type alkaloids present anti-addictive effects against several drugs of abuse and occur in different species of the Apocynaceae family. In this work, we used gas chromatography-mass spectrometry (GC/MS) and principal component analysis (PCA) in order to compare the alkaloid profiles of the root and stem barks of four Mexican Tabernaemontana species with the root bark of...
Chemistry & Biodiversity
December 1, 2016
Felix Krengel, Josefina Herrera Santoyo, Teresa de Jesús Olivera Flores et al.
19 citations
Tabernaemontana alba and Tabernaemontana arborea are Apocynaceae species used in Mexican traditional medicine for which little phytochemical information exists. In this study, preliminary gas chromatography/mass spectrometry analyses of different organs obtained from wild plants of both species identified a total of 10 monoterpenoid indole alkaloids (MIAs) and one simple indole alkaloid, nine...
Chemistry & Biodiversity
May 1, 2009
Daniel Trachsel, David E. Nichols, Stephanie Kidd et al.
15 citations
A series of novel ligands for the serotonin 5-HT(2A/C) receptor subtype bearing the 2-phenylethylamine pharmacophore was synthesized and assayed for its 5-HT(2A) receptor binding affinity. As the 4'-aryl-substituted 2-(2,5-dimethoxyphenyl)ethylamines were previously unknown, an initial series of twelve compounds was chosen to obtain initial insight into their structure-activity relationships....
Chemistry & Biodiversity
July 1, 2007
Yiqiang Li, Stephen M. Husbands, Mary F Mahon et al.
The clerodane diterpenoid salvinorin A (1), the main active component of the psychotropic herb Salvia divinorum, has been reported to be a potent agonist at the kappa-opioid receptor. Computer modeling suggested that splendidin (2) from S. splendens, as well as related compounds, might possess similar activities. In the present study, this hypothesis was tested by determination of the binding...