World Futures
April 29, 2026
Azul Delgrasso, Jay Monger
This article explores how council practice, men’s work, and low-dose 5-MeO-DMT can support the cultivation of transformative leadership in complex, transdisciplinary contexts. Drawing on transformative leadership, integrative transdisciplinarity as an approach to inquiry, and research on transdisciplinary leadership learning, we argue that well-designed relational “containers” can deepen...
Psychedelics
April 25, 2026
Juliet Meccia, David Casimir, Sisi Li et al.
Over the past 25 years, the use of 5-MeO-DMT in informal and underground settings has contributed a substantial, yet underrecognized, body of knowledge relating to the efficacy of 5-MeO-DMT in alleviating depressive symptoms. Traditional models of drug development, typically characterized by structured trials and regulatory milestones, rarely consider findings from these alternative routes. The...
Journal of Psychoactive Drugs
April 23, 2026
Brayan Jonas Mano-Sousa, Maria Clara Gama Fontes, Ana Clara Anacleto Gonçalves et al.
Suicide, particularly in treatment-resistant depression (TRD), remains a pressing global health issue, with over 700,000 annual deaths. Existing treatments often have limited efficacy and delayed onset, creating a need for rapid-acting interventions. Ayahuasca, a traditional Amazonian psychedelic, has shown potential for rapidly reducing suicidal ideation. Our systematic review evaluated the...
Revista Tópicos.
April 22, 2026
Muriel Fernandes, Kelvy Muniz, Débora Barbosa et al.
Este artigo apresenta o protocolo experimental e a base teórica atualizada do Experimento do Século, cujo objetivo central é validar empiricamente a Arquitetura Holográfica da Construção da Realidade (AHCR 2.0), modelo que propõe a consciência como variável físico-informacional mensurável no processo de construção da realidade observável.A origem dessa abordagem remonta à publicação do primeiro...
Zenodo (CERN European Organization for Nuclear Research)
April 18, 2026
We propose a three-phase experimental protocol testing whether the radical pair mechanism (RPM) operates during N,N-dimethyltryptamine (DMT)-induced psychedelicstates at the 5-HT2A receptor. Position-specific isotopic substitution of the ligand (13C at C3a, 15N on indole nitrogen) modifies nuclear spin content without altering molecular geometry, receptor affinity, or metabolic...
Journal of Psychopharmacology
April 12, 2026
L. M. Wallace, Andrea Bujor, Gustavo Sudre et al.
Background: Conventional psychological and pharmacological substance abuse treatments are limited to moderate effect sizes and fail to magnify outcomes when combined. Analog psychedelic agents N, N-dimethyltryptamine (DMT) and 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) show therapeutic potential for treatment-resistant psychiatric disorders including substance addictions. Methods: This...
Zenodo (CERN European Organization for Nuclear Research)
April 2, 2026
David M. Remmer
Alamia et al. (2020) reported that N,N-dimethyltryptamine (DMT) significantly increases forward (bottom-up) cortical travelling waves, based on surrogate-normalized 2D FFT analysis. We reanalyze the same publicly available EEG dataset (N = 12) using the same method, supplemented by absolute power analysis. Absolute forward wave power decreases under DMT in all 12 subjects at alpha (8–13 Hz) and...
Zenodo (CERN European Organization for Nuclear Research)
April 1, 2026
Jon Washburn
N,N-dimethyltryptamine (DMT) is an endogenous tryptamine neurotransmitter whose extracellular concentrations rival serotonin, whose release increases during cardiac arrest, and whose sigma-1 receptor (Sig-1R) activation provides potent neuroprotection against hypoxia. Despite decades of research, no first-principles framework explains why the brain synthesizes a molecule that produces...