The Molecular Key to the Theta Field: A Zero-Parameter Formalization of Endogenous DMT and Consciousness State Transitions
Zenodo (CERN European Organization for Nuclear Research) April 1, 2026 Jon Washburn
N,N-dimethyltryptamine (DMT) is an endogenous tryptamine neurotransmitter whose extracellular concentrations rival serotonin, whose release increases during cardiac arrest, and whose sigma-1 receptor (Sig-1R) activation provides potent neuroprotection against hypoxia. Despite decades of research, no first-principles framework explains why the brain synthesizes a molecule that produces...