Mindfulness-based cognitive therapy for obsessive-compulsive disorder: Study protocol for a randomized controlled trial with functional magnetic resonance imaging and a 6-month follow-up
Lu Lu, Tianran Zhang, Rui Gao, Zongfeng Zhang, CAO Xuan Cuong, Yongjun Chen, Ying Liu, Fei Zhang, Yue Zheng, Yan Sun, Yanle Bai, Jianyu Wang, Fabrizio Didonna, Haiyin Zhang, Qing Fan
Journal of Health Psychology July 5, 2018 DOI: 10.1177/1359105318780540 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial protocol Peer reviewed |
|---|---|
| Sample size | 120 |
| Population | Un-medicated Chinese patients with obsessive-compulsive disorder |
| Interventions | Mindfulness-based cognitive therapy selective serotonin reuptake inhibitor psycho-education |
| Duration | 11 sessions over 10 weeks, with follow-up assessments at 6 months (weeks 14, 22, and 34) |
| Topics | Meditation |
| Citations | 8 |
| Key findings | The protocol describes a single-blind randomized controlled trial designed to test the efficacy and feasibility of mindfulness-based cognitive therapy compared with a selective serotonin reuptake inhibitor and psycho-education in 120 un-medicated Chinese obsessive-compulsive disorder patients, with clinical and functional magnetic resonance imaging assessments across treatment and six-month follow-up. |
Abstract
This article presents a study protocol for a single-blind randomized controlled trial to test the efficacy and feasibility of mindfulness-based cognitive therapy. A total of 120 un-medicated Chinese obsessive-compulsive disorder patients will be randomized to the mindfulness-based cognitive therapy group, the selective serotonin reuptake inhibitor group or the psycho-education group for 11 sessions in 10 weeks. A range of scales for clinical symptoms and functional magnetic resonance imaging will be completed at baseline (week 0), mid-intervention (week 4), post-intervention (week 10) and the 6-month follow-up (weeks 14, 22 and 34). The study will have relevance to decisions about treatment options for un-medicated obsessive-compulsive disorder patients.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cited by 5
- Efficacy and fMRI-based response predictors to mindfulness-based cognitive therapy in obsessive-compulsive disorder: Study protocol for a randomised clinical trial. Revista de Psiquiatría y Salud Mental 2023
- Pallidum volume as a predictor for the effectiveness of mindfulness-based cognitive therapy and psycho-education in unmedicated patients with obsessive-compulsive disorder. Comprehensive Psychiatry May 1, 2024
- Intervensi Mindfuness Behavior Cognitive Therapy (MBCT) dalam Meningkatkan Self Esteem pada Remaja: Literature Review JIIP - Jurnal Ilmiah Ilmu Pendidikan December 1, 2023
- Examination of the Effectiveness of Mindfulness-Based Cognitive Therapy on Patients with Obsessive-Compulsive Disorder: Systematic Review and Meta-Analysis. Issues in Mental Health Nursing May 28, 2021
- Mindfulness-Based Cognitive Therapy for Unmedicated Obsessive-Compulsive Disorder: A Randomized Controlled Trial With 6-Month Follow-Up. Frontiers in Psychiatry 2021
Cites 10
- Using Self-Report Assessment Methods to Explore Facets of Mindfulness Assessment January 27, 2006
- Standardised Mindfulness-Based Interventions in Healthcare: An Overview of Systematic Reviews and Meta-Analyses of RCTs PLoS One April 16, 2015
- [Mindfulness-based interventions in obsessive-compulsive disorder: Mechanisms of action and presentation of a pilot study]. L'Encephale December 2017
- Mindfulness-based cognitive therapy as an augmentation treatment for obsessive-compulsive disorder. Clinical Psychology & Psychotherapy September 2017
- Mindfulness-based interventions for people diagnosed with a current episode of an anxiety or depressive disorder: a meta-analysis of randomised controlled trials. PLoS One June 15, 2016
and 5 more in the library