Mindfulness-based cognitive therapy in obsessive-compulsive disorder: protocol of a randomized controlled trial.
Anne Katrin Külz, Sarah Landmann, Barbara Cludius, Birgit Hottenrott, Nina Rose, Thomas Heidenreich, Elisabeth Hertenstein, Ulrich Voderholzer, Steffen Moritz
BMC Psychiatry November 18, 2014 DOI: 10.1186/s12888-014-0314-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial protocol Peer reviewed |
|---|---|
| Sample size | 128 |
| Population | Patients with a primary diagnosis of OCD according to DSM-IV and no or only partial response to CBT, recruited from in- and outpatient services, online forums, and media |
| Intervention | Mindfulness-based cognitive therapy (MBCT) |
| Duration | 8 weekly sessions of 120 minutes each; follow-up at 6 and 12 months |
| Measures | Yale-Brown-Obsessive-Compulsive Scale (Y-BOCS), approach avoidance task |
| Topics | Meditation |
| Key findings | The authors hypothesize that an 8-week group MBCT program will be superior to a psycho-educative coaching group in reducing obsessive-compulsive symptoms, as measured by the Y-BOCS, after the intervention and at 6- and 12-month follow-up. They state this is the first randomized controlled study assessing MBCT effects on symptom severity and related parameters in OCD. |
Abstract
Obsessive-compulsive disorder (OCD) is a very disabling condition with a chronic course, if left untreated. Though cognitive behavioral treatment (CBT) with or without selective serotonin reuptake inhibitors (SSRI) is the method of choice, up to one third of individuals with obsessive-compulsive disorder (OCD) do not respond to treatment in terms of at least 35% improvement of symptoms. Mindfulness based cognitive therapy (MBCT) is an 8-week group program that could help OCD patients with no or only partial response to CBT to reduce OC symptoms and develop a helpful attitude towards obsessions and compulsive urges. This study is a prospective, bicentric, assessor-blinded, randomized, actively-controlled clinical trial. 128 patients with primary diagnosis of OCD according to DSM-IV and no or only partial response to CBT will be recruited from in- and outpatient services as well as online forums and the media. Patients will be randomized to either an MBCT intervention group or to a psycho-educative coaching group (OCD-EP) as an active control condition. All participants will undergo eight weekly sessions with a length of 120 minutes each of a structured group program. We hypothesize that MBCT will be superior to OCD-EP in reducing obsessive-compulsive symptoms as measured by the Yale-Brown-Obsessive-Compulsive Scale (Y-BOCS) following the intervention and at 6- and 12-months-follow-up. Secondary outcome measures include depressive symptoms, quality of life, metacognitive beliefs, self-compassion, mindful awareness and approach-avoidance tendencies as measured by an approach avoidance task. The results of this study will elucidate the benefits of MBCT for OCD patients who did not sufficiently benefit from CBT. To our knowledge, this is the first randomized controlled study assessing the effects of MBCT on symptom severity and associated parameters in OCD. German Clinical Trials Register DRKS00004525 . Registered 19 March 2013.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cited by 9
- Mindfulness-based cognitive therapy for obsessive-compulsive disorder: Study protocol for a randomized controlled trial with functional magnetic resonance imaging and a 6-month follow-up Journal of Health Psychology July 5, 2018
- The Boy Who Grew a New Brain: Understanding this Miracle from a Neuro-Quantum Perspective NeuroQuantology June 26, 2018
- Pallidum volume as a predictor for the effectiveness of mindfulness-based cognitive therapy and psycho-education in unmedicated patients with obsessive-compulsive disorder. Comprehensive Psychiatry May 1, 2024
- Clinical effects of mindfulness-based interventions for adults with a history of childhood maltreatment: a scoping review. Current Treatment Options in Psychiatry June 2021
- Examination of the Effectiveness of Mindfulness-Based Cognitive Therapy on Patients with Obsessive-Compulsive Disorder: Systematic Review and Meta-Analysis. Issues in Mental Health Nursing May 28, 2021
and 4 more in the library
Cites 18
- Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology 2000
- Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Journal of Consulting and Clinical Psychology 2004
- Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy – a systematic review of randomized controlled trials Acta Psychiatrica Scandinavica April 28, 2011
- Mindfulness training increases momentary positive emotions and reward experience in adults vulnerable to depression: A randomized controlled trial. Journal of Consulting and Clinical Psychology July 18, 2011
- Mindfulness-based cognitive therapy for preventing relapse in recurrent depression: A randomized dismantling trial. Journal of Consulting and Clinical Psychology December 3, 2013
and 13 more in the library