Phenomenology and neurobiology of self disorder in schizophrenia: Primary factors.
Schizophrenia Research December 2015 DOI: 10.1016/j.schres.2015.09.024 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Philosophy of mind |
| Keywords | Neurocognitive models Psychosis Schizophrenia Self-disorder |
| Key points | Argues that schizophrenia is best understood by integrating phenomenological accounts of disturbed basic self-experience with multiple neurobiological correlates, and proposes that early perceptual and motor disturbances—especially impaired multisensory integration ("perceptual dys-integration")—disrupt "grip" on the world, hyperreflexivity, and diminished self-presence, contributing to a neurodevelopmental account of the condition. |
Abstract
Schizophrenia is a heterogeneous syndrome, varying between persons and over course of illness. In this and a companion article, we argue that comprehension of this condition or set of conditions may require combining a phenomenological perspective emphasizing disorders of basic-self experience ("ipseity disturbance") with a multidimensional appreciation of possible neurobiological correlates--both primary and secondary. Previous attempts to link phenomenology and neurobiology generally focus on a single neurocognitive factor. We consider diverse aspects of schizophrenia in light of a diverse, albeit interacting, set of neurocognitive abnormalities, examining both synchronic (structural) interdependence and diachronic (temporal) succession. In this article we focus on the primary or foundational role of early perceptual and motoric disturbances that affect perceptual organization and especially intermodal or multisensory perceptual integration (“perceptual dys-integration”). These disturbances are discussed in terms of their implications for three interconnected aspects of selfhood in schizophrenia, primary forms of: disrupted "hold" or "grip" on the world, hyperreflexivity, diminished self-presence (self-affection). Disturbances of organization or integration imply forms of perceptual incoherence or diminished cognitive coordination. The effect is to disrupt one's ability to apprehend the world in holistic, vital, or contextually grounded fashion, or to fully identify with or experience the unity of one's own body or thinking--thereby generating an early and profound (albeit often subtle) disruption or diminishment of basic or core self and of the sense of existing in a coherent world. We discuss interrelationships or possible complementarities between these three aspects, and consider their relevance for a neurodevelopmental account of schizophrenia.
Comparable studies
Other theoretical and historical papers on philosophy of mind, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | 2003 | Theoretical or philosophical paper | |
| From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis. | 2005 | Theoretical or philosophical paper | |
| How do the brain's time and space mediate consciousness and its different dimensions? Temporo-spatial theory of consciousness (TTC). | 2017 | Theoretical or philosophical paper | |
| The phenomenology of deep brain stimulation-induced changes in OCD: an enactive affordance-based model. | 2013 | Theoretical or philosophical paper | |
| Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution | 2017 | Theoretical or philosophical paper |
Citations in the library
Cited by 19
- The neurophenomenology of early psychosis: An integrative empirical study. Consciousness and Cognition November 1, 2019
- From Self-Esteem to Selflessness: An Evidence (Gap) Map of Self-Related Processes as Mechanisms of Mindfulness-Based Interventions Frontiers in Psychology November 22, 2021
- Basic Self-Disturbances beyond Schizophrenia: Discrepancies and Affinities in Panic Disorder - An Empirical Clinical Study. Psychopathology 2017
- Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia Current Problems of Psychiatry September 1, 2017
- Towards a Neurophenomenological Understanding of Self-Disorder in Schizophrenia Spectrum Disorders: A Systematic Review and Synthesis of Anatomical, Physiological, and Neurocognitive Findings Brain Sciences May 23, 2023
and 14 more in the library
Cites 29
- Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. American Journal of Psychiatry 2003
- Default Mode Network Activity and Connectivity in Psychopathology Annual Review of Clinical Psychology March 29, 2012
- Disturbances in body ownership in schizophrenia: evidence from the rubber hand illusion and case study of a spontaneous out-of-body experience. PLoS One June 10, 2016
- Self-disturbance and schizophrenia: structure, specificity, pathogenesis (Current issues, New directions). Schizophrenia Research 2014
- The Neurodynamic Organization of Modality-Dependent Hallucinations Cerebral Cortex April 24, 2012
and 24 more in the library