"Schizophrenia, Consciousness, and the Self" Twenty Years Later: Revisiting the Ipseity-Disturbance Model and the Developmental Nature of Self-Disorder in the Schizophrenia Spectrum.
Andrea Raballo, Mads Gram Henriksen, Michele Poletti, Josef Parnas
Schizophrenia Bulletin May 25, 2025 DOI: 10.1093/schbul/sbaf071 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Keywords | Hyperreflexivity Ipseity-disorder model Ontogenesis Schizophrenia Schizotaxia Schizotypy Self-disorders self-disturbance Anomalous self-experience Ipseity disorder Early detection |
| Citations | 9 |
| Key findings | Self-disorders are a valuable, quantifiable trait phenotype for genetic liability to schizophrenia spectrum disorders and provide critical insights into the development of clinical manifestations. |
Abstract
Self-disorders (SD) designate a pattern of non-psychotic anomalous self-experiences, which specifically aggregate in clinical and subclinical forms of schizophrenia spectrum disorders (SSD), including familial high-risk configurations. SD have been corroborated as a valuable, quantitatively tractable, trait phenotype for indexing genetic liability to SSD, and, as a risk phenotype, they offer critical insights into the nature of these complex conditions which precede and shape the development of more overt clinical manifestations (including schizotypal features and positive, negative, and disorganized symptoms). In the last three decades, the concept of self-disorders has evolved from early clinical observations to a well-defined research domain, offering a nuanced understanding of schizophrenia spectrum vulnerabilities and holding promise for improving diagnostic accuracy, enhancing prognostic assessments, offering novel targets for intervention, and advancing our understanding of the schizophrenia spectrum.